Rabbit anti-BCAR3 Antibody, Affinity Purified

The epitope recognized by PLA0206 maps to a region between residue 25 and 75 of human breast cancer anti-estrogen resistance 3 using the numbering given in entry NP_003558.1 (GeneID 8412).

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

BCAR3 (breast cancer anti-estrogen resistance 3) was originally identified as a factor that confers resistance to anti-estrogens in breast cancer cells. BCAR3 contains a Ras-GEF domain and an SH2 domain. It is related to SHEP1 and NSP1 and is thought to also play a role as an adaptor protein that mediates integrin signaling to modulate cell adhesion and migration.

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