PRS2221
Anti-BAFF antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-BLyS, Anti-Tall, Anti-Thank, Anti-Tumor necrosis factor (ligand) superfamily, member 13b
产品名称
Anti-BAFF antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 31 kDa
species reactivity
human, rat, mouse
technique(s)
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TNFSF13B(10673)
Biochem/physiol Actions
B cell activating factor (BAFF) participates in B cell and T cell mediated immunity. It plays a key role in the survival and differentiation of B cells. Mutations in BAFF regulates the levels of antibody. BAFF also participates in enhancing the responses of IL-6 (interlukin-6) and TNF-α (tumor necrosis factor alpha), that helps hepatocytes in the production of acute-phase protein.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
B-lymphocyte activating factor (BAFF/TNFSF13B) is a cytokine that belongs to the TNF (tumor necrosis factor) superfamily. BAFF is located on human chromosome 13q33.
Immunogen
a peptide corresponding to amino acids near the carboxy-terminus of human BAFF.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP2221.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system?related LIG4, TNFSF13B and IRS2 genes.
Acevedo N, et al.
Clinical and Experimental Immunology, 157(2), 282-290 (2009)
Polymorphism in the 5′ regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome.
Nossent JC, et al.
Rheumatology (Basel), 47(9), 1311-1316 (2008)
Sung-Sik Yoon et al.
International journal of molecular sciences, 22(13) (2021-07-21)
Fibroblast-like synoviocytes (FLSs) play a key role in the pathogenesis of rheumatoid arthritis (RA) by producing inflammatory cytokines and interacting with various immune cells, which contribute to cartilage destruction. RA-FLSs activated by tumor necrosis factor alpha (TNF-α), exacerbate joint damage
Increased levels of BAFF in patients with systemic lupus erythematosus are associated with acute-phase reactants, independent of BAFF genetics: a case?control study.
Eilertsen G?, et al.
Rheumatology (Basel), 50(12), 2197-2205 (2011)
Association of genetic variation in B-cell activating factor with chronic hepatitis B virus infection.
Han Q, et al.
Immunology Letters, 188, 53-58 (2017)
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