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PRS2265

抗 Nephrin 兔抗

Name: 抗 Nephrin 兔抗
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

别名:

CNF, NPHN, 肾小球特异性细胞粘附受体

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

NP_004637

UniProt accession no.

O60500

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NPHS1(4868)

General description

肾病蛋白（nephrin）在肾小球中强烈表达，是细胞粘附分子免疫球蛋白家族的成员之一。它是一种1241个残基的跨膜蛋白。Nephrin基因的突变会导致先天性肾病综合征，这是一种常染色体隐性遗传疾病，其特征是子宫内有大量蛋白尿和出生时的肾病。肾小球允许正常肾脏过滤血浆，使其非常纯净。Nephrin在肾小球的足细胞裂孔隔膜中表达，其方式表明Nephrin分子以类似于粘附连接中的钙黏着蛋白各种相互作用的反平行方式同型二聚化。因此，肾素可以构成裂孔隔膜的整个细胞外结构。

Immunogen

肾蛋白抗体在人类的羧基末端附近产生抗14个氨基酸的合成肽的抗体
肾蛋白。免疫原位于肾蛋白的最后 50 个氨基酸内。

Physical form

溶于含0.02%叠氮化钠的磷酸盐缓冲盐水中

Other Notes

可以使用阻断肽 SBP2265阻断该抗体的作用。

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除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

wgk

WGK 1

法规信息

常规特殊物品

低风险生物材料

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货号	GTIN
PRS2265-100UG	04061832178592

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