PRS2337
Anti-IKAP antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-IKBKAP, Anti-IKK complex-associated protein, Anti-Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
产品名称
Anti-IKAP antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 134-147 kDa
species reactivity
mouse, human
technique(s)
immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IKBKAP(8518)
Biochem/physiol Actions
Mutations in IKAP cause familial dysautonomia. It helps to conserve the proliferation of neural precursor and blocks its unexpected differentiation into neurons. It plays an important role in cell motility and migration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
IKAP (IKK-complex-associated protein) is considered as a subunit of the RNA Pol II elongator complex. It is also known as IKBKAP (Ikappakinase complex-associated protein or human elongator factor 1) and ELP1 (elongator protein-1). It has 37 exons and codes for 1332 amino acid IKAP protein, that is of ~150KD. It is present in most of the tissues. It is mapped to chromosome 9q31.
Immunogen
a 16 amino acid peptide from near the carboxy-terminus of human IKAP.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP2337.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
IKAP/Elp1 is required in vivo for neurogenesis and neuronal survival, but not for neural crest migration.
Hunnicutt B J,et al.
PLoS ONE, 7(2):e32050 (2012)
Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation.
Lefler S, et al.
PLoS ONE, 10(10):e0138807 (2015)
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