PRS2447
Anti-MTBP antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunofluorescence
indirect ELISA
western blot
immunofluorescence
indirect ELISA
western blot
Species reactivity:
human
Citations:
3
Technique(s):
immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-MTBP antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 104 kDa
species reactivity
human
technique(s)
immunocytochemistry: suitable
immunofluorescence: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MTBP(27085)
Biochem/physiol Actions
The gene MTBP (Mdm2-binding protein) is mapped to human chromosome 8q24. It is involved in the development and progression of cancer. In hepatocellular carcinoma, MTBP enhances MDM2 (E3 ubiquitin-protein ligase)-associated degradation of E-cadherin. It is also suggested as a therapeutic target for treatment of triple-negative breast cancer. MTBP is a transcriptional target of Myc. It plays an important role in cell cycle progression. Silencing of this gene causes delay in cell cycle progress at S and G2/M phases.
Immunogen
a synthetic peptide corresponding to amino acids 122-139 of human MTBP, which differ from mouse by three amino acids.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP2447.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization.
Boyd MT
Cytogenetics and Cell Genetics, 90, 64-65 (2000)
MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.
Grieb BC
Molecular Cancer Research, 12, 1216-1224 (2014)
MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin.
Lu S
Digestive Diseases and Sciences, 60, 3681-3690 (2015)
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