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Merck
CN

Q109

6-Nitroquipazine maleate salt

solid

别名:

6-Nitro-2-(1-piperazinyl)quinoline maleate salt, Du 24565

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关于此项目

经验公式（希尔记法）:
C13H14N4O2 · C4H4O4
化学文摘社编号:
77372-73-7
分子量:
374.35
NACRES:
NA.77
PubChem Substance ID:
24278116
UNSPSC Code:
12352202
MDL number:
MFCD00153868

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InChI

1S/C13H14N4O2.C4H4O4/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16;5-3(6)1-2-4(7)8/h1-4,9,14H,5-8H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.[O-][N+](=O)c1ccc2nc(ccc2c1)N3CCNCC3

InChI key

LXOHMGALVZOYRF-BTJKTKAUSA-N

form

solid

color

yellow

solubility

0.1 M HCl: 16 mg/mL, H2O: 5 mg/mL, methanol: 6 mg/mL, 0.1 M NaOH: insoluble

storage temp.

2-8°C

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Biochem/physiol Actions

Potent and selective serotonin transport blocker.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
011M4708V
028H4639

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K Hashimoto et al.
European journal of pharmacology, 187(3), 295-302 (1990-10-23)
The characteristics of the binding [3H]6-nitroquipazine, a very potent and selective inhibitor of 5-hydroxytryptamine (5-HT; serotonin) uptake, to human platelet membranes were studied at a physiological temperature of 37 degrees C. The presence of a single saturable high-affinity binding component
B S Lee et al.
Bioorganic & medicinal chemistry letters, 10(14), 1559-1562 (2000-07-29)
6-Nitroquipazine has been known as one of the most potent and selective inhibitors of serotonin transporter in vitro and in vivo. Nine derivatives of 6-nitroquipazine were synthesized and tested for their potential abilities to displace [3H]citalopram binding to the rat
K Hashimoto et al.
European journal of pharmacology, 180(2-3), 273-281 (1990-05-16)
6-Nitroquipazine is a very potent and selective inhibitor of neuronal 5-hydroxytryptamine (5-HT; serotonin) uptake. We have characterized the specific binding of [3H]6-nitroquipazine to rat brain membranes at 22 degrees C. The present results indicate the presence of a single saturable
L Descarries et al.
Synapse (New York, N.Y.), 21(2), 131-139 (1995-10-01)
Direct counting of axon terminals (varicosities) labeled by uptake/storage of a tritiated monoamine provides a means to test radioligands of the corresponding membrane transporter as quantitative markers of regional monoamine innervation density in brain tissue. In autoradiographs from alternate rat
Jae Hak Lee et al.
Bioorganic & medicinal chemistry, 15(10), 3499-3504 (2007-03-23)
Five C2'-substituted 6-nitroquipazine (6-NQ) derivatives were prepared and evaluated in terms of their biological abilities (K(i)) to displace [(3)H]citalopram binding to serotonin transporter. The relationship between their structure and biological activities revealed that shorter alkyl groups tend to possess higher
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