Q109
6-Nitroquipazine maleate salt
solid
别名:
6-Nitro-2-(1-piperazinyl)quinoline maleate salt, Du 24565
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关于此项目
经验公式（希尔记法）:
C13H14N4O2 · C4H4O4
化学文摘社编号:
分子量:
374.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C13H14N4O2.C4H4O4/c18-17(19)11-2-3-12-10(9-11)1-4-13(15-12)16-7-5-14-6-8-16;5-3(6)1-2-4(7)8/h1-4,9,14H,5-8H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.[O-][N+](=O)c1ccc2nc(ccc2c1)N3CCNCC3
InChI key
LXOHMGALVZOYRF-BTJKTKAUSA-N
form
solid
color
yellow
solubility
0.1 M HCl: 16 mg/mL, H2O: 5 mg/mL, methanol: 6 mg/mL, 0.1 M NaOH: insoluble
storage temp.
2-8°C
Gene Information
Biochem/physiol Actions
Potent and selective serotonin transport blocker.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Okada et al.
The European journal of neuroscience, 11(1), 1-9 (1999-02-13)
To clarify the effects of adenosine receptor subtypes (A1, A2 and A3) on hippocampal serotonin (5-HT) release and 5-HT reuptake activity, hippocampal extracellular 5-HT levels were determined in vivo by microdialysis in freely moving rats. Selective 5-HT reuptake inhibitor (SSRI)
C A Mathis et al.
The Journal of pharmacy and pharmacology, 46(9), 751-754 (1994-09-01)
The in-vitro inhibition constants (Ki) of nine structural analogues of the potent 5-hydroxytryptamine (5-HT)-uptake inhibitor, 6-nitroquipazine, were determined to assess the structure-affinity relationship of these derivatives. The goal of these studies was to determine those positions on 6-nitroquipazine that could
S Rutz et al.
Neuroscience, 146(2), 643-658 (2007-03-27)
5-HT released from serotonergic axon terminals in the septal nuclei modulates the activity of septal output neurons (e.g. septohippocampal cholinergic neurons) bearing somatodendritic 5-HT receptors. Therefore, we studied the mechanisms involved in the presynaptic modulation of 5-HT release in the
Byung Seok Moon et al.
Bioorganic & medicinal chemistry, 13(16), 4952-4959 (2005-07-05)
On the basis of the structure-activity relationship (SAR) of 4-chloro-6-nitroquipazine (Ki = 0.03 nM) and 3-fluoropropyl-6-nitroquipazine (Ki = 0.32 nM), 3-alkyl-4-halo-6-nitroquipazines were synthesized and tested for their potential abilities in vitro to displace [3H]citalopram binding to the rat cortical membranes.
K Classen et al.
Naunyn-Schmiedeberg's archives of pharmacology, 326(3), 198-202 (1984-06-01)
Rat brain cortex slices were prepared in order to study the influence of DU 24565 (6-nitroquipazine) and quipazine on the accumulation of tritium, and to investigate the effects of DU 24565 on the electrically evoked (3 Hz) tritium overflow from
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