Merck
CN

HTR4

5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled

Synonyms:
5-HT4, 5-HT4R
Species:
Human HTR4 (3360), Mouse Htr4 (15562), Rat Htr4 (25324), Horse HTR4 (100034053), domestic cat HTR4 (101088723), sheep HTR4 (101117928), cow HTR4 (317708), domestic guinea pig Htr4 (100135548), chicken HTR4 (416150), dog HTR4 (489198)
UniProtKB ID:
Q13639, Q546Q1, Q684M0, Q712M9, Q96KH9, Q96KI0, Q9H199, Q9NY73
Gene ID:
  • Human(3360) Summary: This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]
  • Mouse(15562) 5 hydroxytryptamine (serotonin) receptor 4
  • Rat(25324) 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
  • Horse(100034053) 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
  • domestic cat(101088723) 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
  • sheep(101117928) 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
  • cow(317708) 5-hydroxytryptamine (serotonin) receptor 4
  • domestic guinea pig(100135548) 5 hydroxytryptamine (serotonin) receptor 4
  • chicken(416150) 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
  • dog(489198) 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
  • naked mole-rat(101707865) 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled

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Small Molecule - Agonist

Product Number
Description
Species
SML1504
Tegaserod maleate, ≥98% (HPLC),
Species
human
M1824990
Metoclopramide, European Pharmacopoeia (EP) Reference Standard,
Species
human
BP357
Metoclopramide hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
32473
Metoclopramide, VETRANAL®, analytical standard,
Species
human
M0763
Metoclopramide hydrochloride, solid,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
D9190
DCEBIO, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
S3313
SB-204070 hydrochloride, solid, ≥97% (HPLC),
Species
human
M7319
ML 10302, ≥98%, solid,
Species
rat
M1824990
Metoclopramide, European Pharmacopoeia (EP) Reference Standard,
Species
human
BP357
Metoclopramide hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human
G5918
GR 113808, ≥98% (HPLC), solid,
Species
rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
HPA040591
Anti-HTR4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
SAB2101109
Anti-HTR4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, human, rabbit
Application
western blot
SAB4501480
Anti-5-HT-4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot

Small Molecule - Blocker

Product Number
Description
Species
T3146
Trimipramine maleate salt, ≥98% (TLC), powder,
Species
human

Small Molecule - Inhibitor

Product Number
Description
Species
F1678
R-(−)-Fluoxetine hydrochloride, >98% (HPLC), solid,
Species
human
F1553
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Species
human
C7861
Citalopram hydrobromide, ≥98% (HPLC),
Species
human
F132
Fluoxetine hydrochloride, solid,
Species
human
F2802
Fluvoxamine maleate, solid,
Species
human

Small Molecule - Ligand

Product Number
Description
Species
M1514
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Species
human

Small Molecule - Metabolite

Product Number
Description
Species
H8876
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Species
human

Small Molecule - Precursor

Product Number
Description
Species
H9772
5-Hydroxy-L-tryptophan, powder,
Species
human

esiRNA

Product Number
Description
Species
EHU070651
MISSION® esiRNA, targeting human HTR4,
Species
human