R0758
Ritodrine hydrochloride
β2 adrenoceptor agonist
别名:
N-(p-Hydroxyphenethyl)-4-hydroxynorephedrine hydrochloride
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关于此项目
经验公式（希尔记法）:
C17H21NO3 · HCl
化学文摘社编号:
分子量:
323.81
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
245-514-8
MDL number:
产品名称
Ritodrine hydrochloride,
InChI key
IDLSITKDRVDKRV-XHXSRVRCSA-N
InChI
1S/C17H21NO3.ClH/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13;/h2-9,12,17-21H,10-11H2,1H3;1H/t12-,17-;/m0./s1
SMILES string
Cl.C[C@H](NCCc1ccc(O)cc1)[C@H](O)c2ccc(O)cc2
originator
AstraZeneca
Quality Level
Gene Information
human ... ADRB2(154)
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Biochem/physiol Actions
β2-adrenoceptor agonist; relaxes uterine muscle contraction.
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
A Kimura et al.
Endocrinology, 140(2), 722-731 (1999-02-02)
The regulation of mitogen-activated protein (MAP) kinase by endothelin-1 (ET-1) in cultured rat puerperal uterine myometrial cells was investigated. ET-1 caused the rapid stimulation of MAP kinase activity. ET-1-induced MAP kinase activation is neither extracellular Ca2+- nor intracellular Ca2+-dependent. ET-1
J M Bassett et al.
The American journal of physiology, 275(1 Pt 2), R112-R119 (1998-08-05)
Prolonged administration of the beta2-adrenergic agonist ritodrine to fetal sheep increases nonesterified fatty acid mobilization. To investigate whether changes in fetal growth or functional development of brown adipose tissue (BAT) also occur, ritodrine was infused at 5 microg/min iv into
S Bertini et al.
General pharmacology, 31(4), 625-631 (1998-10-29)
1. The involvement of beta3 adrenoceptors in the control of gastric acid secretion and histamine release was investigated in the dog. 2. In conscious dogs, SR 58611A (0.0625-1.0 mg/kg/hr i.v.) dose dependently inhibited gastric acid secretion induced by pentagastrin. Maximal
Hiraku Onishi et al.
International journal of pharmaceutics, 468(1-2), 207-213 (2014-04-09)
Ritodrine hydrochloride (RD-HCl) tablets containing alginate (AL) and lactose (LC) with or without microcrystalline cellulose (MC) as excipients were produced as a buccal dosage form. The RD-HCl (2 mg) tablets with AL/LC but no MC swelled and dissolved gradually in
Simona Codruţa Cobzac et al.
Journal of chromatographic science, 52(9), 1095-1103 (2013-10-29)
The retention behavior for a series of amine neurotransmitters, their precursors, metabolites and structurally related drugs has been investigated in reversed-phase thin-layer chromatography using RP-18, RP-8, RP-2, CN and Diol stationary phases and mixtures of phosphate buffer and methanol as
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