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Merck
CN

R2530

Sigma-Aldrich

罗匹尼罗 盐酸盐

≥98% (HPLC), D2 and D3 dopamine receptor agonist, powder

别名:

4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride, SKF 101468 hydrochloride

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关于此项目

经验公式（希尔记法）:
C16H24N2O · HCl
CAS Number:
91374-20-8
分子量:
296.84
MDL编号:
MFCD01754173
UNSPSC代码:
12352200
PubChem化学物质编号:
329824018
NACRES:
NA.77

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Product Name

罗匹尼罗 盐酸盐, powder, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

light yellow

溶解性

H2O: >10 mg/mL

创始人

GlaxoSmithKline

SMILES字符串

Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12

InChI

1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H

InChI key

XDXHAEQXIBQUEZ-UHFFFAOYSA-N

基因信息

human ... DRD2(1813), DRD3(1814), DRD4(1815)

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相关类别

生化/生理作用

An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.
Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.
Selective D2 dopamine receptor agonist, antiparkinsonian

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险声明

H302,H400

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000219161
0000219161
0000184635
0000187658
0000187659

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Carlo Tessa et al.
Parkinsonism & related disorders, 19(2), 265-268 (2012-08-21)
Previous fMRI studies indicated a relationship between changes of the cortical activation pattern and disease severity in Parkinson's disease (PD). Early diagnosis of Parkinson's disease offers the opportunity to evaluate the putative neuroprotective and disease-modifying effects of drugs at a
Sébastien Duband et al.
Journal of forensic and legal medicine, 19(7), 422-425 (2012-08-28)
Ropinirole, a specific non-ergoline dopamine D2-receptor agonist, belongs to the drugs applied in treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) and acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D3. Therapeutic
Ropinirole for the treatment of early Parkinson's disease
Adler C H, et al.
Neurology, 49(2), 393-399 (1997)
Ropinirole as an effective adjunctive treatment for clozapine-resistant negative symptoms in simple schizophrenia: a case report.
Panayiota G Michalopoulou et al.
Journal of clinical psychopharmacology, 32(5), 719-720 (2012-08-29)
Spontaneous unwelcome orgasms due to pramipexole and ropinirole.
Oliver Kaut et al.
Movement disorders : official journal of the Movement Disorder Society, 27(10), 1327-1328 (2012-08-21)
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