R2530
罗匹尼罗 盐酸盐
≥98% (HPLC), D2 and D3 dopamine receptor agonist, powder
别名:
SKF 101468 hydrochloride, 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride
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关于此项目
经验公式（希尔记法）:
C16H24N2O · HCl
化学文摘社编号:
分子量:
296.84
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
罗匹尼罗 盐酸盐, powder, ≥98% (HPLC)
SMILES string
Cl.CCCN(CCC)CCc1cccc2NC(=O)Cc12
InChI key
XDXHAEQXIBQUEZ-UHFFFAOYSA-N
InChI
1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
light yellow
solubility
H2O: >10 mg/mL
originator
GlaxoSmithKline
Quality Level
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815)
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Biochem/physiol Actions
An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors. Used as antiparkinsonian drug.
Ropinirole hydrochloride is effectively used to treat early and late Parkinson′s disease.
Selective D2 dopamine receptor agonist, antiparkinsonian
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Carlo Tessa et al.
Parkinsonism & related disorders, 19(2), 265-268 (2012-08-21)
Previous fMRI studies indicated a relationship between changes of the cortical activation pattern and disease severity in Parkinson's disease (PD). Early diagnosis of Parkinson's disease offers the opportunity to evaluate the putative neuroprotective and disease-modifying effects of drugs at a
Spontaneous unwelcome orgasms due to pramipexole and ropinirole.
Oliver Kaut et al.
Movement disorders : official journal of the Movement Disorder Society, 27(10), 1327-1328 (2012-08-21)
Ropinirole for the treatment of early Parkinson's disease
Adler C H, et al.
Neurology, 49(2), 393-399 (1997)
Ropinirole as an effective adjunctive treatment for clozapine-resistant negative symptoms in simple schizophrenia: a case report.
Panayiota G Michalopoulou et al.
Journal of clinical psychopharmacology, 32(5), 719-720 (2012-08-29)
Josef Finsterer et al.
Acta neurologica Belgica, 111(4), 321-324 (2012-03-01)
Whether a dopamine-deficiency syndrome in a Parkinson-syndrome (PS) may occur more easily during a heat wave than during more temperate climate conditions is unknown. We report a case that may suggest this. A 56 yo male with heterozygosity for metachromatic
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