R3905
Ro273225 三氟乙酸盐
≥98% (reversed phase HPLC)
别名:
Butir-His-D-Phe-Arg-Trp-Sar-NH2 三氟乙酸盐
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关于此项目
经验公式（希尔记法）:
C39H52N12O6 · xC2HF3O2
化学文摘社编号:
分子量:
784.91 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (reversed phase HPLC)
Form:
lyophilized solid
Quality Segment
assay
≥98% (reversed phase HPLC)
form
lyophilized solid
color
white
solubility
H2O: >10 mg/mL
storage temp.
room temp
SMILES string
CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)CC(N)=O
InChI
1S/C39H52N12O6/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44)/t29-,30-,31-,32-/m0/s1
InChI key
NINOPZAAGJJNAR-YDPTYEFTSA-N
Biochem/physiol Actions
Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.
Ro 27-3225 is a selective melanocortin MC4 receptor agonist.
Features and Benefits
This compound is featured on the Melanocortin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
Eyeshields, Gloves, type N95 (US)