R3905
Ro273225 三氟乙酸盐
≥98% (reversed phase HPLC)
别名:
Butir-His-D-Phe-Arg-Trp-Sar-NH2 三氟乙酸盐
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关于此项目
经验公式（希尔记法）:
C39H52N12O6 · xC2HF3O2
化学文摘社编号:
分子量:
784.91 (free base basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Quality Level
assay
≥98% (reversed phase HPLC)
form
lyophilized solid
color
white
solubility
H2O: >10 mg/mL
storage temp.
room temp
SMILES string
CCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)CC(N)=O
InChI
1S/C39H52N12O6/c1-3-10-34(53)47-31(19-26-21-43-23-46-26)37(56)49-30(17-24-11-5-4-6-12-24)36(55)48-29(15-9-16-44-39(41)42)35(54)50-32(38(57)51(2)22-33(40)52)18-25-20-45-28-14-8-7-13-27(25)28/h4-8,11-14,20-21,23,29-32,45H,3,9-10,15-19,22H2,1-2H3,(H2,40,52)(H,43,46)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H4,41,42,44)/t29-,30-,31-,32-/m0/s1
InChI key
NINOPZAAGJJNAR-YDPTYEFTSA-N
Biochem/physiol Actions
Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.
Ro 27-3225 is a selective melanocortin MC4 receptor agonist.
Features and Benefits
This compound is featured on the Melanocortin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Francina Agosti et al.
The European journal of neuroscience, 40(5), 2755-2765 (2014-06-20)
The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor involved in food intake and energy expenditure regulation. MC4R activation modifies neuronal activity but the molecular mechanisms by which this regulation occurs remain unclear. Here, we tested the hypothesis that
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| R3905-1MG | 04061836695163 |