R4528
Anti-hnRNP-A1 antibody, Mouse monoclonal
clone 9H10, purified from hybridoma cell culture
别名:
Anti-heterogeneous nuclear ribonucleoprotein-A1
产品名称
Anti-hnRNP-A1 antibody, Mouse monoclonal, clone 9H10, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
9H10, monoclonal
form
buffered aqueous solution
mol wt
antigen ~34 kDa
species reactivity
human, hamster, monkey, rat, bovine, mouse, canine
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using total cell extract of 293T cells
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HNRNPA1(3178)
mouse ... Hnrnpa1(15382)
rat ... Hnrnpa1(29578)
Application
Anti-hnRNP-A1 has been used in immunofluorescence, immunohistochemistry and western blotting.
Does not immunoprecipitate the hnRNP complex.
Does not immunoprecipitate the hnRNP complex.
Biochem/physiol Actions
hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) participates in several RNA metabolisms. It also participates in deep vein thrombosis patients with behçet′s disease. hnRNPA1 mutations results in amyotrophic lateral sclerosis and multisystem proteinopathy.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) is a pre-mRNA/mRNA binding protein, that belongs to the hnRNP family. It is located in chromosome 12q13.1. It is located in the nucleoplasm but it travels between the nucleus and the cytoplasm. It has two RNP motif RNA-binding domains (RBDs) at the amino terminus and a glycine-rich domain at the carboxyl terminus.
Immunogen
purified human hnRNP-A1.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
HnRNP A1 is Involved in Deep Vein Thrombosis Patients with Behcet's Disease
Chen P, et al.
EBioMedicine, 6, 215-221 (2016)
hnRNPA1 autoregulates its own mRNA expression to remain non-cytotoxic
Suzuki H and Matsuoka M
Molecular and Cellular Biochemistry, 427(1-2), 123-131 (2017)
Novel somatic single nucleotide variants within the RNA binding protein hnRNP A1 in multiple sclerosis patients
Lee S and Levin M
F1000Research, 3:132 (2014)
Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus
Liu C and Gotz J
PLoS ONE, 8(12) (2013)
A nuclear localization domain in the hnRNP A1 protein
Siomi H and Dreyfuss G
The Journal of Cell Biology, 129(3), 551-560 (1995)
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