R5278
抗 RAGE（晚期糖基化终产物受体） 兔抗
affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat
technique(s)
immunohistochemistry: 1-2 μg/mL using transgenic mouse retina, western blot: 1 μg/mL using using mouse lung extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AGER(177)
mouse ... Ager(11596)
rat ... Ager(81722)
General description
晚期糖基化终产物受体（RAGE），也称为晚期糖基化终产物特异性受体（AGER），由定位于人染色体6p21的基因编码。编码的蛋白质是细胞表面分子免疫球蛋白超家族的成员。
Immunogen
对应于大鼠RAGE氨基酸残基362-380的合成肽。该序列在小鼠中100%保守，在人中70%保守。
Biochem/physiol Actions
晚期糖基化终产物（RAGE）受体的可溶形式在Wnt途径中具有功能。RAGE在炎症和细胞损伤以及细胞毒性的发展中起作用。它与糖尿病性动脉粥样硬化有关。AGER/RAGE还调节细胞增殖、分化和凋亡。{93
Physical form
溶于含0.1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水中。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Association of RAGE gene Gly82Ser polymorphism with coronary artery disease and ischemic stroke
Ma W Q, et al.
Medicine, 95(49) (2016)
Susmita Barman et al.
Chemico-biological interactions, 307, 37-50 (2019-04-23)
Zinc depletion during diabetes postulates a role for zinc nutrition in the management of associated complications. The present study evaluated zinc supplementation for countering the compromised intestinal integrity through moderation of oxidative stress and suppression of stress-stimulated inflammatory proliferation in
Association of Polymorphisms of the Receptor for Advanced Glycation Endproducts Gene with Schizophrenia in a Han Chinese Population
Fu J, et al.
BioMed Research International (2017)
Is there a role for high mobility group box 1 and the receptor for advanced glycation end products in the genesis of long-term cognitive impairment in sepsis survivors?
Felipe Dal-Pizzol et al.
Molecular medicine (Cambridge, Mass.), 18, 1357-1358 (2012-11-02)
Circulating sRAGE in the diagnosis of osteolytic bone metastasis.
Galliera E
Journal of Biological Regulators and Homeostatic Agents, 30(4), 1203-1208 (2016)
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