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Merck
CN

S0697

Anti-Sortilin 兔抗

lyophilized powder, affinity isolated antibody

别名:

Anti-SORT1

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
4
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biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat, human

technique(s)

immunohistochemistry: suitable, western blot: 1:200 using rat brain lysates

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SORT1(6272)
mouse ... Sort1(20661)
rat ... Sort1(83576)

General description

Sortilin is neurotensin receptor 3 (NTS3), one of the receptors for the peptide neurotransmitter neurotensin that exerts several biological functions ranging from the regulation of dopamine transmission and pain in the central nervous system to its functioning as a local hormone affecting the gastrointestinal tract. Sortilin expression was found to be essential for proNGF and proBDNF-induced neuronal cell death

Immunogen

peptide DKDTTRRIHVSTDQD(C) corresponding to residues 320-335 of human sortilin.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

Preparation Note

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
低风险生物材料

此项目有



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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相关内容

Instructions


Margalida Cifre et al.
Molecular neurodegeneration, 13(1), 14-14 (2018-03-24)
Metabolically-obese, normal-weight (MONW) individuals are not obese in terms of weight and height but have a number of obesity-related features (e.g. greater visceral adiposity, insulin resistance, and increased risk of cardiovascular disease). The MONW phenotype is related to the intake
Gregory T Jones et al.
Human molecular genetics, 22(14), 2941-2947 (2013-03-29)
Abdominal aortic aneurysm (AAA) is a common human disease with a high estimated heritability (0.7); however, only a small number of associated genetic loci have been reported to date. In contrast, over 100 loci have now been reproducibly associated with
Idy H T Ho et al.
Theranostics, 9(6), 1651-1665 (2019-05-01)
Rationale: Brain-derived neurotrophic factor (BDNF) is a key mediator in the development of chronic pain. Sortilin is known to interact with proBDNF and regulate its activity-dependent secretion in cortical neurons. In a rat model of inflammatory pain with intraplantar injection



全球贸易项目编号

货号GTIN
S0697-200UL04061838173973
S0697-50UL04061838032973