S1190
Anti-SLIPR/MAGI-3 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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关于此项目
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IF, WB CL
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 140-160 kDa
species reactivity
rat
technique(s)
indirect immunofluorescence: 2.0 μg/mL using 293T cells transfected with recombinant Slipr., microarray: suitable, western blot (chemiluminescent): 1.0 μg/mL using extracts of 293T cells transfected with recombinant Slipr
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Magi3(245903)
General description
MAGI-3 possesses a guanylate-kinase-like region, six PDZ and two WW domains. This gene is located on human chromosome 1p13.
The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.2
MAGI-3 (also termed SLIPR) was identified in a two hybrid screening as a protein interacting with the tumor suppressor PTEN,6 and Receptor Tyrosine Phosphatase β (RPTPβ).7
MAGI-3 (also termed SLIPR) was identified in a two hybrid screening as a protein interacting with the tumor suppressor PTEN,6 and Receptor Tyrosine Phosphatase β (RPTPβ).7
Immunogen
synthetic peptide corresponding to amino acids 835-850 of SLIPR (rat homolog of MAGI-3) conjugated to KLH via a N-terminal added lysine residue.
Biochem/physiol Actions
Membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) serves as a scaffold protein for frizzled-4 and Ltap . It helps to control the c-Jun N-terminal kinase (JNK) signaling cascade.
Staining by immunoblotting and immunofluorescence is specifically inhibited by the immunizing peptide.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins
Adamsky K, et al.
Journal of Cell Science, 116(7), 1279-1289 (2003)
Genome wide identification of new genes and pathways in patients with both autoimmune thyroiditis and type 1 diabetes
Tomer Y, et al.
Journal of Autoimmunity, 60, 32-39 (2015)
Ryoji Yao et al.
Oncogene, 23(36), 6023-6030 (2004-06-15)
A seven-transmembrane protein, frizzled, has been implicated in a planar cell polarity (PCP) pathway as well as the canonical Wnt signaling pathway. Although both pathways require a cytoplasmic protein, dishevelled, the molecular mechanism by which frizzled regulates intracellular signaling remains
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