Anti-SLIPR/MAGI-3 antibody produced in rabbit

MAGI-3 possesses a guanylate-kinase-like region, six PDZ and two WW domains. This gene is located on human chromosome 1p13.

The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.²

MAGI-3 (also termed SLIPR) was identified in a two hybrid screening as a protein interacting with the tumor suppressor PTEN,⁶ and Receptor Tyrosine Phosphatase β (RPTPβ).⁷

synthetic peptide corresponding to amino acids 835-850 of SLIPR (rat homolog of MAGI-3) conjugated to KLH via a N-terminal added lysine residue.

Membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) serves as a scaffold protein for frizzled-4 and Ltap . It helps to control the c-Jun N-terminal kinase (JNK) signaling cascade.

Staining by immunoblotting and immunofluorescence is specifically inhibited by the immunizing peptide.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide as a preservative.

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