S1198
Sumatriptan succinate
≥98% (HPLC), solid, 5-HT₁ receptor agonist
别名:
3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate, GR-43175
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关于此项目
经验公式（希尔记法）:
C14H21N3O2S · C4H6O4
化学文摘社编号:
分子量:
413.49
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Sumatriptan succinate, ≥98% (HPLC), solid
SMILES string
OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
InChI key
PORMUFZNYQJOEI-UHFFFAOYSA-N
InChI
1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
assay
≥98% (HPLC)
form
solid
color
white to beige
solubility
H2O: >20 mg/mL
originator
GlaxoSmithKline
Quality Level
Gene Information
human ... HTR1B(3351), HTR1D(3352)
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Biochem/physiol Actions
Sumatriptan succinate has the ability to constrict human cranial arteries. This 5-HT1 receptor agonist can be used to treat migraine.
Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Treatment of acute migraine with subcutaneous sumatriptan
Cady RK, et al.
JAMA : The Journal of the American Medical Association, 265(21), 2831-2835 (1991)
Mucoadhesive bilayered patches for administration of sumatriptan succinate
Shidhaye SS, et al.
Aaps Pharmscitech, 9(3), 909-916 (2008)
Tse-Ming Chou et al.
The journal of headache and pain, 23(1), 157-157 (2022-12-13)
To investigate specific brain regions and neural circuits that are responsible for migraine chronification. We established a mouse model of chronic migraine with intermittent injections of clinically-relevant dose of nitroglycerin (0.1 mg/kg for 9 days) and validated the model with cephalic and
Jeong Ju Seo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 919-920, 38-42 (2013-02-16)
A sensitive and simple detection method coupling ultra-performance liquid chromatography with tandem mass spectrometry was developed and validated to analyze sumatriptan levels in human plasma. The plasma sample preparations for the analysis were based on liquid-liquid extraction with ethyl acetate
Y Sekino et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(12), 1083-e564-1083-e564 (2012-08-14)
Oral sumatriptan administration has been reported to delay gastric emptying after liquid meals. The aim of this study was to determine whether delayed gastric emptying is caused by enhanced gastric accommodation, impaired antral contractions, or both using ultrasonography. Ten healthy
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