Merck
CN
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文件

S1688

Sigma-Aldrich

SR 57227A

solid

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别名:
4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride
经验公式（希尔记法）:
C10H14ClN3 · HCl
CAS号:
77145-61-0
分子量:
248.15
MDL编号:
MFCD01756430
PubChem化学物质编号:
24278109
NACRES:
NA.77

形式

solid

质量水平

100

颜色

white

溶解性

H2O: soluble 9 mg/mL

SMILES字符串

Cl.NC1CCN(CC1)c2cccc(Cl)n2

InChI

1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H

InChI key

FUMINTAAUJUVMP-UHFFFAOYSA-N

基因信息

human ... HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)

应用

SR 57227A may be used in 5-HT3-mediated cell signaling studies.

生化/生理作用

SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.
Potent and selective 5-HT3 serotonin receptor agonist.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Erin E Shannon et al.
Alcohol (Fayetteville, N.Y.), 37(1), 35-45 (2006-02-14)
Neurosteroids represent a class of endogenous compounds that exert rapid, nongenomic effects through neurotransmitter receptor systems such as gamma-aminobutyric acid(A) (GABA(A)). Two neurosteroids, allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one) and pregnanolone (3alpha-hydroxy-5beta-pregnan-20-one), possess anxiolytic and sedative properties and show substitution for ethanol, benzodiazepines, and
A Bachy et al.
European journal of pharmacology, 237(2-3), 299-309 (1993-06-24)
SR 57227A (4-amino-(6-chloro-2-pyridyl)-1 piperidine hydrochloride) is a novel compound with high affinity and selectivity for the 5-HT3 receptor. The compound had affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on
K Watanabe et al.
European journal of pharmacology, 350(2-3), 181-188 (1998-08-08)
In this study, we assessed the effects of the acute administration of various 5-HT receptor agonists on hippocampal partial seizures generated by low-frequency electrical stimulation in male Wistar rats. The seizure threshold and severity were determined by measuring the pulse
E Edwards et al.
Brain research, 733(1), 21-30 (1996-09-09)
The aim of the study was to further characterize the pharmacological properties of 5-hydroxytryptamine (5-HT)3-like receptors in the rat medial prefrontal cortex (mPFC) using combinations of biochemical and electrophysiological approaches. Phenylbiguanide (PBG) and three chlorinated derivatives, ortho-chloro-PBG (oCPBG), meta-chloro-PBG (mCPBG)
Heba Abdel-Aziz et al.
European journal of pharmacology, 530(1-2), 136-143 (2005-12-21)
Ginger (rhizomes of Zingiber officinale) has been shown to exert potent anti-emetic properties, but its mode of action has not yet been elucidated. Among its active constituents, [6]-, [8]- and [10]-gingerol as well as [6]-shogaol were shown in different in
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