S1688
SR 57227A
solid
别名:
4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C10H14ClN3 · HCl
化学文摘社编号:
分子量:
248.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
SMILES string
Cl.NC1CCN(CC1)c2cccc(Cl)n2
InChI key
FUMINTAAUJUVMP-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: soluble 9 mg/mL
Quality Level
Gene Information
human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
相关类别
Application
SR 57227A may be used in 5-HT3-mediated cell signaling studies.
Biochem/physiol Actions
Potent and selective 5-HT3 serotonin receptor agonist.
SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
L Staner et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 11(4), 301-305 (2001-09-05)
The respective role of various classes of central serotonin (5-HT) receptors in the regulation of sleep-wakefulness cycles has been the subject of many studies. Notably, it has been reported that 5-HT1A/B receptors are involved in the regulation of rapid eye
Z H Gui et al.
Neuroscience, 169(3), 1315-1325 (2010-06-26)
In the present study, we examined changes in the firing rate and firing pattern of putative slow-spiking (SS) and fast-spiking (FS) interneurons in medial prefrontal cortex (mPFC) and the effect of 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist SR 57227A on the neuronal
J Y Zhang et al.
Neuropharmacology, 33(3-4), 483-491 (1994-03-01)
The techniques of extracellular single cell recording and microiontophoresis were used to study the effect of 5-HT3 receptor agonists on glutamate-activated firing of CA1 hippocampal pyramidal cells. Iontophoretic application of 5-HT3 receptor agonists 2-methyl-5-HT and SR 57227A produced a current
Takahiro Hayashi et al.
Neuroscience research, 66(1), 22-29 (2009-09-22)
The serotonin type 3 (5-HT(3)) receptor is an only ligand-gated ion channel among 14 serotonin receptors. Here, we examined the roles of the 5-HT(3) receptor in the formation of dendrites and axons, using a dissociation culture of embryonic rat cerebral
Michel M M Verheij et al.
Psychopharmacology, 205(3), 441-455 (2009-05-13)
The mechanisms underlying individual differences in the response to serotonergic drugs are poorly understood. Rat studies may contribute to our knowledge of the neuronal substrates that underlie these individual differences. A pharmacobehavioural study was performed to assess individual differences in
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