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Merck
CN

S174

Sigma-Aldrich

SDZ-205,557 hydrochloride

solid

别名:

4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride

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关于此项目

经验公式(希尔记法):
C14H21ClN2O3 · HCl
化学文摘社编号:
分子量:
337.24
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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表单

solid

颜色

off-white

溶解性

DMSO: 100 mg/mL
H2O: 65 mg/mL
ethanol: insoluble

创始人

Sandoz

SMILES字符串

Cl[H].CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC

InChI

1S/C14H21ClN2O3.ClH/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3;/h8-9H,4-7,16H2,1-3H3;1H

InChI key

JOWUQCJWCRNVMQ-UHFFFAOYSA-N

基因信息

human ... HTR4(3360)

生化/生理作用

Potent, selective 5-HT4 serotonin receptor antagonist.

特点和优势

This compound was developed by Sandoz. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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N Amemiya et al.
European journal of pharmacology, 318(2-3), 403-409 (1996-12-30)
This study examined effects of 5-methoxytryptamine (5-MOT), an agonist at 5-HT4 and 5-HT2B receptors, on the contractile response and acetylcholine release in rat stomach fundus strips. 5-MOT (10(-9)-10(-5) M) produced a concentration-dependent increase in the contraction, while it evoked acetylcholine
G E Torres et al.
The Journal of pharmacology and experimental therapeutics, 271(1), 255-261 (1994-10-01)
The study of serotonin-4 (5-HT4) receptors in the central nervous system has been hindered by the lack of effective, selective antagonists. However, recently, several novel compounds have been synthesized and shown to act as antagonists at 5-HT4 receptors in smooth
J Lorrain et al.
European journal of pharmacology, 229(1), 105-108 (1992-12-08)
Putative 5-HT4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD2 of 6.7. Its effects were antagonised in a selective and competitive manner by
C M Franks et al.
The Journal of pharmacy and pharmacology, 47(3), 213-218 (1995-03-01)
The involvement of the recently characterized 5-HT4 receptor in the actions of 5-hydroxytryptamine (5-HT) on jejunal, ileal and colonic electrogenic ion secretion was investigated in the rat in-vivo. 5-HT and the 5-HT1-, 5-HT2- and 5-HT4-receptor agonist 5-methoxytryptamine (5-MeOT), induced a
J Coleman et al.
Naunyn-Schmiedeberg's archives of pharmacology, 352(1), 74-78 (1995-07-01)
A putative 5-HT4 receptor-mediated depolarization of the rat isolated vagus nerve has been studied using a grease-gap extracellular recording technique. Ondansetron (1 microM) was used to block the predominant 5-HT3 receptor mediated depolarization in this preparation and the effects of

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