S174
SDZ-205,557 hydrochloride
solid
别名:
4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
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关于此项目
经验公式（希尔记法）:
C14H21ClN2O3 · HCl
化学文摘社编号:
分子量:
337.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C14H21ClN2O3.ClH/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3;/h8-9H,4-7,16H2,1-3H3;1H
SMILES string
Cl[H].CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC
InChI key
JOWUQCJWCRNVMQ-UHFFFAOYSA-N
form
solid
color
off-white
solubility
DMSO: 100 mg/mL, H2O: 65 mg/mL, ethanol: insoluble
originator
Sandoz
Gene Information
human ... HTR4(3360)
Biochem/physiol Actions
Potent, selective 5-HT4 serotonin receptor antagonist.
Features and Benefits
This compound was developed by Sandoz. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
K H Buchheit et al.
Naunyn-Schmiedeberg's archives of pharmacology, 345(4), 387-393 (1992-04-01)
A selective antagonist for the recently characterized 5-HT4 receptor is lacking. The only surmountable antagonist available, ICS 205-930, is a weak antagonist and is far more potent at 5-HT3-than at 5-HT4 receptors. In this paper, SDZ 205-557 (2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino)
Y Nagakura et al.
Naunyn-Schmiedeberg's archives of pharmacology, 353(5), 489-498 (1996-04-01)
We examined the effects of exogenous 5-hydroxytryptamine (5-HT) and selective 5-HT receptor agonists and antagonists on proximal, middle and distal colonic motility in conscious fasted dogs with extraluminal force transducers implanted chronically. 5-HT (0.003-0.1 mg/kg i.v.) dose-dependently enhanced motility along
E F Espejo et al.
Brain research, 788(1-2), 20-24 (1998-05-21)
The role of 5-HT4 receptors on cutaneous and visceral pain remains largely unexplored. The objective of this study was to establish the activity profile of SDZ 205-557, a 5-HT4 antagonist, on cutaneous (hotplate) and visceral (writhing) models of pain, after
J F Kuemmerle et al.
Gastroenterology, 109(6), 1791-1800 (1995-12-01)
The type and function of 5-hydroxytryptamine (5HT) receptors on intestinal muscle cells in humans are not known. 5-HT receptors were characterized pharmacologically and by radioligand binding. Contraction, relaxation, inositol 1,4,5-triphosphate (IP3) and adenosine 3',5'-cyclic monophosphate (cAMP) formation, and 5-HT binding
P Rondé et al.
The Journal of pharmacology and experimental therapeutics, 272(3), 977-983 (1995-03-01)
We have studied agonist-induced desensitization of 5-hydroxytryptamine (5-HT4) receptor-mediated relaxation and 5-HT4 receptor-mediated increases in cAMP in rat esophageal tunica muscularis mucosae. In both cases, the desensitization time course was biphasic. The first phase was very rapid because more than
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