S174
SDZ-205,557 hydrochloride
solid
别名:
4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
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关于此项目
经验公式（希尔记法）:
C14H21ClN2O3 · HCl
化学文摘社编号:
分子量:
337.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
form
solid
color
off-white
solubility
DMSO: 100 mg/mL, H2O: 65 mg/mL, ethanol: insoluble
originator
Sandoz
SMILES string
Cl[H].CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC
InChI
1S/C14H21ClN2O3.ClH/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3;/h8-9H,4-7,16H2,1-3H3;1H
InChI key
JOWUQCJWCRNVMQ-UHFFFAOYSA-N
Gene Information
human ... HTR4(3360)
Biochem/physiol Actions
Potent, selective 5-HT4 serotonin receptor antagonist.
Features and Benefits
This compound was developed by Sandoz. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J Coleman et al.
Naunyn-Schmiedeberg's archives of pharmacology, 352(1), 74-78 (1995-07-01)
A putative 5-HT4 receptor-mediated depolarization of the rat isolated vagus nerve has been studied using a grease-gap extracellular recording technique. Ondansetron (1 microM) was used to block the predominant 5-HT3 receptor mediated depolarization in this preparation and the effects of
C M Franks et al.
The Journal of pharmacy and pharmacology, 47(3), 213-218 (1995-03-01)
The involvement of the recently characterized 5-HT4 receptor in the actions of 5-hydroxytryptamine (5-HT) on jejunal, ileal and colonic electrogenic ion secretion was investigated in the rat in-vivo. 5-HT and the 5-HT1-, 5-HT2- and 5-HT4-receptor agonist 5-methoxytryptamine (5-MeOT), induced a
Y Nagakura et al.
The Journal of pharmacology and experimental therapeutics, 281(1), 284-290 (1997-04-01)
We have already reported that 5-hydroxytryptamine3 (5-HT3) receptor antagonists failed to modify 5-HT-accelerated colonic transit in conscious rats, but the 5-HT3 and 5-HT4 receptor dual antagonist FK1052 prevented the enhancement. In this study, the inhibitory effect on the stimulated colonic
G E Torres et al.
The Journal of pharmacology and experimental therapeutics, 271(1), 255-261 (1994-10-01)
The study of serotonin-4 (5-HT4) receptors in the central nervous system has been hindered by the lack of effective, selective antagonists. However, recently, several novel compounds have been synthesized and shown to act as antagonists at 5-HT4 receptors in smooth
J Lorrain et al.
European journal of pharmacology, 229(1), 105-108 (1992-12-08)
Putative 5-HT4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD2 of 6.7. Its effects were antagonised in a selective and competitive manner by
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S174-5MG | 04061832093406 |
| S174-25MG | 04061832093390 |
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