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安全信息

S2071

Sigma-Aldrich

Anti-Sodium Channel NaV1.8 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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别名:
Anti-PN3, Anti-SCN10A
MDL编号:
MFCD08705520
NACRES:
NA.41

生物来源

rabbit

质量水平

200

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

lyophilized powder

种属反应性

rat

技术

immunohistochemistry (frozen sections): suitable using adult rat DRG
western blot: 1:200 using rat DRG lysates

UniProt登记号

Q62968

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... SCN10A(6336)
mouse ... Scn10a(20264)
rat ... Scn10a(29571)

一般描述

Sodium voltage-gated channel α subunit 10 (SCN10A) codes for Nav1.8 sodium channels. It is expressed in nociceptive neurons. This gene is mapped to human chromosome 3p22.2.

免疫原

peptide (C)EDEVAAKEGNSPGPQ corresponding to residues 1943-1957 of rat Nav1.8. This sequence has 14/15 residues identical in mouse and 7/15 residues identical in human.

应用

Anti-Sodium Channel NaV1.8 antibody has been used in immunohistochemistry and immunocytochemistry.

生化/生理作用

Sodium voltage-gated channel α subunit 10 (SCN10A) plays a major role in human pain. It is involved in the pathophysiology of cerebellar deficits in MS (multiple sclerosis).

目标描述

Anti-Sodium Channel NaV1.8 specifically recognizes NaV1.8. Voltage-gated sodium channels (VGSCs) are present in most excitable cells. They play a crucial role in regulating the cell excitability, being primarily responsible for the

外形

Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05 % sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

11 - Combustible Solids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation.
Delaney JT, et al.
Europace, 16(4), 485-490 (2013)
Channelopathy-related SCN10A gene variants predict cerebellar dysfunction in multiple sclerosis.
Roostaei T, et al.
Neurology, 86(5), 410-417 (2016)
A SCN10A SNP biases human pain sensitivity.
Duan G, et al.
Molecular Pain, 12, 1744806916666083-1744806916666083 (2016)
Functional NaV1. 8 Channels in Intracardiac NeuronsNovelty and Significance: The Link Between SCN10A and Cardiac Electrophysiology.
Verkerk AO, et al.
Circulation Research, 111(3), 333-343 (2012)
Tomislav Kokotović et al.
Frontiers in molecular neuroscience, 14, 720973-720973 (2021-10-15)
PR domain-containing member 12 (PRDM12) is a key developmental transcription factor in sensory neuronal specification and survival. Patients with rare deleterious variants in PRDM12 are born with congenital insensitivity to pain (CIP) due to the complete absence of a subtype

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