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S2816

SKF-83959 hydrobromide

Name: SKF-83959 hydrobromide
Brand: SIGMA

≥98% (HPLC), solid

别名:

6-Chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₀NClO₂ · HBr

化学文摘社编号:

80751-85-5

分子量:

398.72

NACRES:

NA.77

PubChem Substance ID:

24278699

UNSPSC Code:

12352200

MDL number:

MFCD03792727

Assay:

≥98% (HPLC)

Form:

solid

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属性

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

SMILES string

Br[H].CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c3cccc(C)c3

InChI

1S/C18H20ClNO2.BrH/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19;/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3;1H

InChI key

FHYWNBUFNGHNCP-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

说明

Application

SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice.

Biochem/physiol Actions

D₁ dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.

SKF-83959 is an atypical agonist of D₁ dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D₁ receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D₁ receptors coupled to adenylyl cyclase.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000389825

0000176744

0000134741

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全球贸易项目编号

货号	GTIN
S2816-25MG	04061832093475
S2816-5MG	04061832093482