产品名称
抗-Sirt3 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~28 kDa
species reactivity
human
technique(s)
indirect immunofluorescence: suitable
western blot: 2.5-5 μg/mL using human HepG2 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SIRT3(23410)
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
Sirtuin 3（Sirt3）是定位于线粒体基质的NAD依赖性脱乙酰基酶。SIRT3编码一个44 kDa的全长形式和一个N端142个氨基酸的截短形式。它位于人染色体11p15.5。
Immunogen
对应于人SIRT3第384-399个氨基酸的合成肽，通过N-末端的半胱氨酸残基与KLH发生偶联。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Biochem/physiol Actions
Sirtuin 3（Sirt3）主要是一种核蛋白，在细胞应激期间转移到线粒体中。在人类中，Sirt3脱乙酰基并激活线粒体酶乙酰辅酶A合成酶1（AceCS2）。Sirt3与调节棕色脂肪细胞的线粒体功能和生热有关。已证明其水平与延长寿命相关。Sirt3水平升高与淋巴结阳性乳腺癌有关。
Application
兔抗Sirt3抗体还可用于蛋白质印迹。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Yihang Zhao et al.
Translational cancer research, 12(12), 3629-3640 (2024-01-09)
Exploring the potential mechanism of cholangiocarcinoma (CCA) metabolic reprogramming is significant for guiding clinical treatment. However, related research and exploration are still lacking. Therefore, we aimed to identify a reliable metabolism-related gene or biomarker of CCA using bioinformatics analysis. The
SIRT2 promotes the migration and invasion of gastric cancer through RAS/ERK/JNK/MMP-9 pathway by increasing PEPCK1-related metabolism
Li Y, et al.
Neoplasia, 20(7), 745-756 (2018)
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
Scher MB, et al.
Genes & Development, 21(8), 920-928 (2007)
Komuraiah Myakala et al.
The Journal of biological chemistry, 299(8), 104975-104975 (2023-07-11)
Diabetes mellitus is the leading cause of cardiovascular and renal disease in the United -States. Despite the beneficial interventions available for patients with diabetes, there remains a need for additional therapeutic targets and therapies in diabetic kidney disease (DKD). Inflammation
SIRT3: oncogene and tumor suppressor in cancer
Torrens-Mas M, et al.
Cancers, 9(7), 90-90 (2017)
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