生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~28 kDa
种属反应性
human
技术
indirect immunofluorescence: suitable
western blot: 2.5-5 μg/mL using human HepG2 cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SIRT3(23410)
一般描述
Sirtuin 3(Sirt3)是定位于线粒体基质的NAD依赖性脱乙酰基酶。SIRT3编码一个44 kDa的全长形式和一个N端142个氨基酸的截短形式。它位于人染色体11p15.5。
免疫原
对应于人SIRT3第384-399个氨基酸的合成肽,通过N-末端的半胱氨酸残基与KLH发生偶联。
应用
兔抗Sirt3抗体还可用于蛋白质印迹。
生化/生理作用
Sirtuin 3(Sirt3)主要是一种核蛋白,在细胞应激期间转移到线粒体中。在人类中,Sirt3脱乙酰基并激活线粒体酶乙酰辅酶A合成酶1(AceCS2)。Sirt3与调节棕色脂肪细胞的线粒体功能和生热有关。已证明其水平与延长寿命相关。Sirt3水平升高与淋巴结阳性乳腺癌有关。
外形
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Yihang Zhao et al.
Translational cancer research, 12(12), 3629-3640 (2024-01-09)
Exploring the potential mechanism of cholangiocarcinoma (CCA) metabolic reprogramming is significant for guiding clinical treatment. However, related research and exploration are still lacking. Therefore, we aimed to identify a reliable metabolism-related gene or biomarker of CCA using bioinformatics analysis. The
SIRT2 promotes the migration and invasion of gastric cancer through RAS/ERK/JNK/MMP-9 pathway by increasing PEPCK1-related metabolism
Li Y, et al.
Neoplasia, 20(7), 745-756 (2018)
Komuraiah Myakala et al.
The Journal of biological chemistry, 299(8), 104975-104975 (2023-07-11)
Diabetes mellitus is the leading cause of cardiovascular and renal disease in the United -States. Despite the beneficial interventions available for patients with diabetes, there remains a need for additional therapeutic targets and therapies in diabetic kidney disease (DKD). Inflammation
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress
Scher MB, et al.
Genes & Development, 21(8), 920-928 (2007)
Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13
Bellizzi D, et al.
Genomics, 89(1), 143-150 (2007)
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