S4322
抗 Sirt6（N-末端） 兔抗
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
抗 NAD 依赖性去乙酰化酶 6, 抗 SIR2-类蛋白 6, 抗 SIR2L6
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
13
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
rat (predicted), mouse, human
packaging
antibody small pack of 25 μL
concentration
~1 mg/mL
technique(s)
western blot: 2-4 μg/mL using whole extracts of human 293 cells transfected with Sirt6, western blot: 2-4 μg/mL using whole extracts of mouse 3T3 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SIRT6(51548)
rat ... Sirt6(299638)
相关类别
General description
Sirtuin 6（Sirt6）是一种染色质相关核蛋白，属于哺乳动物Sir2基因家族。它在肌肉、大脑和心脏中以最高水平广泛表达。
Immunogen
通过 C-末端半胱氨酸残基相应的于人 Sirt6 氨基酸 19-33 的合成肽。该序列在小鼠中相同，在大鼠中相差 1 个氨基酸。
Application
兔抗Sirt6（N末端）抗体可用于免疫印迹。
Biochem/physiol Actions
Anti-Sirt6（N-端）可识别人和小鼠的 Sirt6。通过免疫印迹检测 Sirt6 条带可被免疫肽特异性抑制。
Sirtuin 6 (Sirt6) 在细胞DNA修复和基因组稳定性的维持中起关键作用。作为NAD+依赖性蛋白脱乙酰酶Sirt6没有酶活性，但是具有自身ADP-核糖基转移酶活性。Sirt6的缺失导致急性退行性衰老样表型的出现。
Physical form
溶于 0.01 M 磷酸盐缓冲液（pH 7.4，含 15 mM 叠氮化钠）中。
Disclaimer
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Sergii Domanskyi et al.
Apoptosis : an international journal on programmed cell death, 22(11), 1336-1343 (2017-09-01)
Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we
Differential expression of sirtuin family members in the developing, adult, and aged rat brain
Sidorova-Darmos E, et al.
Frontiers in Aging Neuroscience, 6 (2014)
Justin W Nicholatos et al.
Acta neuropathologica communications, 6(1), 120-120 (2018-11-10)
Parkinson's disease is characterized by progressive death of dopaminergic neurons, leading to motor and cognitive dysfunction. Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson's. We report that nicotine reduces the abundance of SIRT6 in
Protective effect of pyrroloquinoline quinine on ultraviolet A xn-irradiationinduced-fm9j human dermal fibroblast senescence in vitro proceeds via the xn-antiapoptotic-sm6g sirtuin 1/nuclear xn-factorderived-um6g erythroid xn-2related-9m3d factor 2/heme oxygenase 1 pathway
Zhang C, et al.
Molecular Medicine Reports, 12 (2015)
Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
Liszt G, et al.
Test, 280 (2005)
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