S4322
抗 Sirt6（N-末端） 兔抗
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
抗 NAD 依赖性去乙酰化酶 6, 抗 SIR2-类蛋白 6, 抗 SIR2L6
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
western blot
western blot
Species reactivity:
rat (predicted), mouse, human
Citations:
13
Technique(s):
western blot: 2-4 μg/mL using whole extracts of human 293 cells transfected with Sirt6
western blot: 2-4 μg/mL using whole extracts of mouse 3T3 cells
western blot: 2-4 μg/mL using whole extracts of mouse 3T3 cells
Uniprot accession no.:
产品名称
抗 Sirt6（N-末端） 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
rat (predicted), mouse, human
packaging
antibody small pack of 25 μL
concentration
~1 mg/mL
technique(s)
western blot: 2-4 μg/mL using whole extracts of human 293 cells transfected with Sirt6
western blot: 2-4 μg/mL using whole extracts of mouse 3T3 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SIRT6(51548)
rat ... Sirt6(299638)
相关类别
Application
兔抗Sirt6（N末端）抗体可用于免疫印迹。
Biochem/physiol Actions
Anti-Sirt6（N-端）可识别人和小鼠的 Sirt6。通过免疫印迹检测 Sirt6 条带可被免疫肽特异性抑制。
Sirtuin 6 (Sirt6) 在细胞DNA修复和基因组稳定性的维持中起关键作用。作为NAD+依赖性蛋白脱乙酰酶Sirt6没有酶活性，但是具有自身ADP-核糖基转移酶活性。Sirt6的缺失导致急性退行性衰老样表型的出现。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
Sirtuin 6（Sirt6）是一种染色质相关核蛋白，属于哺乳动物Sir2基因家族。它在肌肉、大脑和心脏中以最高水平广泛表达。
Immunogen
通过 C-末端半胱氨酸残基相应的于人 Sirt6 氨基酸 19-33 的合成肽。该序列在小鼠中相同，在大鼠中相差 1 个氨基酸。
Physical form
溶于 0.01 M 磷酸盐缓冲液（pH 7.4，含 15 mM 叠氮化钠）中。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Protective effect of pyrroloquinoline quinine on ultraviolet A xn-irradiationinduced-fm9j human dermal fibroblast senescence in vitro proceeds via the xn-antiapoptotic-sm6g sirtuin 1/nuclear xn-factorderived-um6g erythroid xn-2related-9m3d factor 2/heme oxygenase 1 pathway
Zhang C, et al.
Molecular Medicine Reports, 12 (2015)
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Mostoslavsky R, et al.
Cell, 124 (2006)
Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
Liszt G, et al.
Test, 280 (2005)
Sergii Domanskyi et al.
Apoptosis : an international journal on programmed cell death, 22(11), 1336-1343 (2017-09-01)
Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we
Differential expression of sirtuin family members in the developing, adult, and aged rat brain
Sidorova-Darmos E, et al.
Frontiers in Aging Neuroscience, 6 (2014)
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