S7696
Anti-Sec23 兔抗
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Sec23-related protein A, Anti-Sec23A, Anti-protein transport protein Sec23A
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB CL
Citations:
10
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~75 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using human HeLa cells, western blot (chemiluminescent): 1-2 μg/mL using whole extracts of mouse NIH-3T3 and rat ROS cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SEC23A(10484)
mouse ... Sec23a(20334)
rat ... Sec23a(58817)
General description
Sec23 has two isoforms, Sec23A and Sec23B. Sec23A is mainly found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles.
Sec23A (Sec23 homolog A) is a human Sec23 paralog, that is a GTPase-activating protein. It is a fundamental constituent of the coat protein II complex. It is located on human chromosome 14q21.
Immunogen
synthetic peptide corresponding to amino acid residues 1-18 of human Sec23A with C-terminal added cysteine conjugated to KLH. The corresponding sequence is identical in rat and mouse Sec23A and differs by one amino acid in human and mouse Sec23B.
Application
Anti-Sec23 antibody has been used in immunoblotting, in western blot analysis, immunofluorescence.
Biochem/physiol Actions
Sec23A (Sec23 homolog A) plays an important role in protein trafficking between the endoplasmic reticulum and Golgi apparatus. It also participates in anti-tumorigenesis. Suppressing the expression of Sec23A induces multiplication, migration, and invasion of CRC cells (colorectal cancer). Mutation in SEC23A gene results in cranio-lenticulo-sutural dysplasia.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport
Cutrona M B, et al.
Traffic, 14(6), 691-708 (2013)
Downregulation of Sec23A protein by miRNA-375 in prostate carcinoma
Szczyrba J, et al.
Molecular Cancer Research, 9(6), 791-800 (2011)
Inherited hematological disorders due to defects in coat protein (COP)II complex
Russo R, et al.
American Journal of Hematology, 88(2), 135-140 (2013)
CREB3L1-mediated functional and structural adaptation of the secretory pathway in hormone-stimulated thyroid cells
Garcia I A, et al.
Journal of Cell Science, 130(24), 4155-4167 (2017)
MicroRNA-21 promotes proliferation, migration, and invasion of colorectal cancer, and tumor growth associated with down-regulation of sec23a expression
Li C, et al.
BMC Cancer, 16 (2016)
相关内容
Instructions
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