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Merck
CN

S8070

Anti-SUMO-1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

别名:

Anti-GMP1, Anti-PIC1, Anti-SMT3C, Anti-SMT3H3, Anti-Sentrin-1, Anti-Small Ubiquitin-related Modifiier-1, Anti-UBL1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02096449
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IF, IP, WB
Citations:
22

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 14 kDa (unconjugated SUMO-1), antigen 41 kDa (SUMO-1-GST)

species reactivity

human

technique(s)

immunoprecipitation (IP): 10-20 μg using a nuclear extract of HeLa cells, indirect immunofluorescence: 4-8 μg/mL using human HeLa cells, microarray: suitable, western blot: 0.5-1 μg/mL using nuclear extract of HeLa cells

UniProt accession no.

P63165

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

cow ... SUMO1(614967)
human ... SUMO1(7341)
mouse ... Sumo1(22218)
rat ... Sumo1(301442)

General description

The SUMO-1 (small ubiquitin-like modifier 1) gene is mapped to human chromosome 2q33.1 and is highly conserved. The protein structure includes an α-helix core surrounded by four-stranded β-sheets.

Immunogen

synthetic peptide corresponding to amino acid 1-16 located at the N-terminus of human SUMO-1, conjugated to KLH. The sequence is identical in many species including mouse, rat, dog, bovine, and highly conserved (single amino acid substitution) in chicken and Xenopus SUMO-1. It is not found in human SUMO-2 and SUMO-3.

Application

Anti-SUMO-1 antibody produced in rabbit has been used in immunoblotting assay.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

SUMO (small ubiquitin-like modifier) proteins are associated with a number of cellular processes. SUMOylation mediated by SUMO1 is involved in nuclear transport mechanism, apoptosis, regulation of cyclin-dependent kinase 6 and protein stability. SUMO1 regulates tumor suppressor p53 protein, a transcription factor that is termed as the “guardian of the genome” plays a key role in the cell cycle events. Unlike ubiquitination which directs proteins for degradation, SUMOylation aims to alter the stability, localization and the function of the target protein.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

低风险生物材料
常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000080666
0000085783
0000085783
0000080666
028M4760V

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Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation.
Liu J, et al.
Oncotarget, 7(16), 22206-22206 (2016)
Variants of transient receptor potential melastatin member 4 in childhood atrioventricular block.
Syam N, et al.
Journal of the American Heart Association, 5(5), e001625-e001625 (2016)
Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer.
Ke J, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(9), 12203-12211 (2016)
SUMOylation represses the transcriptional activity of the Unfolded Protein Response transducer ATF6.
Hou X, et al.
Biochemical and Biophysical Research Communications, 494(3), 446-451 (2017)
A Central Cysteine Residue Is Essential for the Thermal Stability and Function of SUMO-1 Protein and SUMO-1 Peptide?Protein Conjugates.
Drobecq H, et al.
Bioconjugate Chemistry, 27(6), 1540-1546 (2016)
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相关内容

Data Sheet - S8070

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