S8260
沙丁胺醇
≥96% (GC), powder, β2 adrenoceptor agonist
别名:
α-[（叔-丁基氨基）甲基]-4-羟基-间-二甲苯-α,α′-二醇, Albuterol
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关于此项目
经验公式（希尔记法）:
C13H21NO3
化学文摘社编号:
分子量:
239.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
242-424-0
MDL number:
Beilstein/REAXYS Number:
6405698
产品名称
沙丁胺醇,
Quality Segment
solubility
methanol: complete 50 mg/ml, clear, colorless to yellow
originator
GlaxoSmithKline
SMILES string
CC(C)(C)NCC(O)c1ccc(O)c(CO)c1
InChI
1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
InChI key
NDAUXUAQIAJITI-UHFFFAOYSA-N
Gene Information
human ... ADRB2(154)
Application
Salbutamol was administered to primate model to study the bronchoconstriction in chronic allergic asthma.20 Salbutamol was used as a standard for rapid pharmacokinetic screening of human plasma samples using HPLC.21
Biochem/physiol Actions
β2-肾上腺素受体激动剂
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1B
存储类别
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves