S8260
沙丁胺醇
≥96% (GC), powder, β2 adrenoceptor agonist
别名:
α-[（叔-丁基氨基）甲基]-4-羟基-间-二甲苯-α,α′-二醇, Albuterol
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关于此项目
经验公式（希尔记法）:
C13H21NO3
化学文摘社编号:
分子量:
239.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
242-424-0
MDL number:
Beilstein/REAXYS Number:
6405698
产品名称
沙丁胺醇,
InChI
1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
InChI key
NDAUXUAQIAJITI-UHFFFAOYSA-N
SMILES string
CC(C)(C)NCC(O)c1ccc(O)c(CO)c1
solubility
methanol: complete 50 mg/ml, clear, colorless to yellow
originator
GlaxoSmithKline
Quality Level
Gene Information
human ... ADRB2(154)
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Biochem/physiol Actions
β2-肾上腺素受体激动剂
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
Application
Salbutamol was administered to primate model to study the bronchoconstriction in chronic allergic asthma.20 Salbutamol was used as a standard for rapid pharmacokinetic screening of human plasma samples using HPLC.21
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1B
存储类别
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
Huib A M Kerstjens et al.
The Lancet. Respiratory medicine, 3(5), 367-376 (2015-02-16)
In patients with severe asthma, tiotropium improves lung function and exacerbation risk when added to high-dose inhaled corticosteroids plus long-acting β2 agonists. We aimed to assess the safety and efficacy of tiotropium in patients with moderate asthma who were symptomatic
James Fingleton et al.
The Journal of allergy and clinical immunology, 136(3), 601-609 (2015-03-10)
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous disorders encompassing different phenotypes of airflow obstruction, which might differ in their response to treatment. The aim of this study was to determine distinct phenotypes comprising the syndromes of asthma and
M Reza Maleki-Yazdi et al.
Respiratory medicine, 108(12), 1752-1760 (2014-12-03)
Combinations of inhaled long-acting bronchodilator therapies such as muscarinic antagonists and β2-agonists may be more effective than monotherapy in the treatment of chronic obstructive pulmonary disease (COPD). This study was a 24-week, Phase III, multicenter, randomized, blinded, double-dummy, parallel-group study
Anna Zaia Carolina Rodrigues et al.
Molecular and cellular neurosciences, 95, 59-70 (2019-02-15)
Increasing evidence indicates that, first, the sympathetic nervous system interacts extensively with both vasculature and skeletal muscle fibers near neuromuscular junctions (NMJs) and, second, its neurotransmitter, noradrenaline, influences myofiber molecular composition and function and motor innervation. Since sympathomimetic agents have
Kirti Singh et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 168, 115763-115763 (2023-10-23)
Asthma and other airway obstructive disorders are characterized by heightened inflammation and excessive airway epithelial cell reactive oxygen species (ROS), which give rise to a highly oxidative environment. After decades of use, β2-adrenergic receptor (β2AR) agonists remain at the forefront
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