跳转至内容
Merck
CN

S8809

Pan单克隆抗 钠通道 小鼠抗

~1 mg/mL, clone K58/35, purified immunoglobulin

别名:

钠通道抗体

登录 查看组织和合同定价。

选择尺寸

关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02097413
Conjugate:
unconjugated
Clone:
K58/35, monoclonal
Application:
IF, IHC (f), WB
Citations:
122

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

K58/35, monoclonal

species reactivity

mammals

concentration

~1 mg/mL

technique(s)

immunohistochemistry (frozen sections): suitable, indirect immunofluorescence: 1 μg/mL using sciatic and optic nerve sections; cultured hypocampal neurons, western blot: 1 μg/mL using crude brain membrane prep (rat)

isotype

IgG1

UniProt accession no.

P35498

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN8A(6334), SCN9A(6335)
mouse ... Scn10a(20264), Scn11a(24046), Scn1a(20265), Scn3a(20269), Scn4a(110880), Scn5a(20271), Scn8a(20273), Scn9a(20274)
rat ... Scn10a(29571), Scn11a(29701), Scn1a(81574), Scn3a(497770), Scn4a(25722), Scn5a(25665), Scn8a(29710), Scn9a(78956)

相关类别

General description

电压门控钠通道/VGSCs（Nav）是由膜的去极化启动的跨膜蛋白。它们是具有大的成孔 α-亚基和小的 β-亚基的异质多聚体。

Immunogen

来自细胞内 III-IV Na + 通道环的合成肽 CTEEQKKYYNAMKKLGSKK

Application

小鼠单克隆抗钠通道泛抗体可用于：
  • 免疫组化（1:50）
  • 免疫染色（1:200）
  • 免疫荧光
  • 免疫细胞化学（1:100）

Biochem/physiol Actions

电压门控钠通道/VGSCs（Nav）参与伤害性传导。它们在调节胞外和胞内空间之间的交换方面发挥着关键作用。VGSC 对于动作电位的启动和激发至关重要。它们参与神经元的兴奋性。因此，VGSC 基因的突变会导致几种癫痫疾病。
该克隆识别的序列在所有已知脊椎动物的 Na + 通道中是相同的。在培养的海马神经元中，该抗体可特异性染色轴突起始段。在坐骨神经和视神经中，它可染色郎飞结。

Physical form

溶液含 10 mM Tris (pH 7.5)、 0.1 mNaCl、30% 甘油和 15 mM 叠氮化钠。

Legal Information

由SUNY Stony Brook 独家授权销售。

Disclaimer

除非我们的产品目录或产品随附的其他公司文件中另有说明，否则我们的产品仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途或任何类型的人类或动物消费或应用。

未找到合适的产品？  

试试我们的产品选型工具.

法规信息

低风险生物材料
常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000398915
0000398915
SLCP9342
SLCL3608
SLCF0620

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Analgesic and antipyretic natural products
Shilpi JA and Uddin SJ
Annual Reports in Medicinal Chemistry, 55, 435-458 (2020)
Amanda L York et al.
eNeuro, 4(4) (2017-08-12)
The neuromuscular junction (NMJ) is a chemical synapse formed between motoneurons and skeletal muscle fibers. The vertebrate NMJ uses acetylcholine (ACh) as the neurotransmitter and features numerous invaginations of the postsynaptic muscle membrane termed junctional folds. ACh receptors (AChRs) are
Marie K Bosch et al.
Channels (Austin, Tex.), 10(4), 297-312 (2016-02-19)
Intracellular Fibroblast Growth Factor 14 (iFGF14) and the other intracellular FGFs (iFGF11-13) regulate the properties and densities of voltage-gated neuronal and cardiac Na(+) (Nav) channels. Recent studies have demonstrated that the iFGFs can also regulate native voltage-gated Ca(2+) (Cav) channels.
J-C Platel et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(52), 19174-19179 (2005-12-17)
Before synaptogenesis, early excitability implicating voltage-dependent and transmitter-activated channels is known to be crucial for neuronal development. We previously showed that preplate (PP) neurons of the mouse neocortex express functional Na(+) channels as early as embryonic day 12. In this
Alexander Drobyshevsky et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 25(25), 5988-5997 (2005-06-25)
Disruption of oligodendrocyte lineage progression is implicated in the white-matter injury that occurs in cerebral palsy. We have previously published a model in rabbits consistent with cerebral palsy. Little is known of normal white-matter development in perinatal rabbits. Using a
查看所有相关文献

相关内容

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持