S9317
PAR-2 (1-6) 酰胺（小鼠、大鼠） 三氟乙酸盐
≥97% (HPLC), proteinase-activated receptor 2 peptide agonist, solid
别名:
PAR2-AP, SLIGRL−NH2, Ser-Leu-Ile-Gly-Arg-Leu-酰胺 三氟乙酸盐
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关于此项目
经验公式（希尔记法）:
C29H56O7N10 · C2HF3O2
分子量:
770.84
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.32
产品名称
PAR-2 (1-6) 酰胺（小鼠、大鼠） 三氟乙酸盐, ≥97% (HPLC)
质量水平
方案
≥97% (HPLC)
表单
solid
储存温度
−20°C
SMILES字符串
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O
InChI
1S/C29H56N10O7/c1-7-17(6)23(39-27(45)21(12-16(4)5)38-25(43)18(30)14-40)28(46)35-13-22(41)36-19(9-8-10-34-29(32)33)26(44)37-20(24(31)42)11-15(2)3/h15-21,23,40H,7-14,30H2,1-6H3,(H2,31,42)(H,35,46)(H,36,41)(H,37,44)(H,38,43)(H,39,45)(H4,32,33,34)/t17-,18-,19-,20-,21-,23-/m0/s1
InChI key
SGPMJRPYYIJZPC-JYAZKYGWSA-N
Amino Acid Sequence
Ser-Leu-Ile-Gly-Arg-Leu-NH2
应用
PAR-2 (1-6) 酰胺（小鼠、大鼠）三氟乙酸盐已被用作蛋白酶激活受体 2（PAR-2） 激动剂，以诱导 Hek293A 细胞中 Hh 和 Hippo 基因的表达。
生化/生理作用
选择性蛋白酶激活受体 2（PAR2） 肽激动剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Hyun Su Ha et al.
Archives of pharmacal research, 40(12), 1443-1454 (2017-11-04)
Protease-activated receptors (PARs) are a family of G protein-coupled receptors with a unique activation mechanism involving proteolytic cleavage of the extracellular N-terminal domain of the receptor. PAR2 has a contractile effect on esophageal smooth muscle. We investigate the signaling pathways
Fiorentina Roviezzo et al.
British journal of pharmacology, 174(22), 4032-4042 (2016-09-15)
The majority of the severe vascular complications in fibrosis are a consequence of a deregulated activity of mediators controlling vasomotor tone. One of the most important of these mediators is endothelin-1 (ET-1). Here, we have investigated the role of proteinase-activated
The Yes-associated protein controls the cell density regulation of Hedgehog signaling
M. Tariki
Oncogenesis (2014)
Chihiro Hirai et al.
Reproductive sciences (Thousand Oaks, Calif.), 23(11), 1542-1550 (2016-05-04)
The production of soluble fms-like tyrosine kinase 1 (sFLT1) by exogenous chymotrypsin in trophoblast cells through protease-activated receptor (PAR) 2 was investigated to identify the role of a chymotrypsin-like serine protease in preeclampsia (PE) pathogenesis. We evaluated the expression of
William G Darby et al.
Pharmacological research, 133, 152-159 (2018-05-23)
The aim of this study was to better understand the role of TRPV4 in the regulation of blood vessel dilatation by blood flow and activation of GPCRs. Using pressure myography, the dilator responses to the TRPV4 agonist GSK1016790A and to
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