SAB1103260
抗 DCAF15 (567-580) 兔抗
IgG fraction of antiserum
别名:
抗C19orf72, 抗DDB1和CUL4相关因子15
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~66 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DCAF15(90379)
General description
DCAF15蛋白是E3连接酶的受体底物。该蛋白是cullin 4-RING (CRL4)-DCAF15 E3泛素连接酶的一部分。
人染色体中的DCAF15基因[DNA损伤结合蛋白1 (DDB1) 和cullin4 (CUL4) 相关因子15]位于19p13.12。DCAF15缺少蛋白相互作用结构域。
Immunogen
对应于人DCAF15氨基酸567-580的合成肽
Application
兔源DCAF15 (567-580) 抗体可用于蛋白印迹。
Biochem/physiol Actions
DCAF15基因[DNA损伤结合蛋白1 (DDB1) 和cullin4 (CUL4) 相关因子15]是裂殖酵母 (Saccharomyces pombe) 许可因子和DNA复制因子 (Cdt2) 的脊椎动物直系同源基因，是人细胞S期中和DNA损伤后破坏Cdt1的必需因子。
DCAF15蛋白在各种癌细胞系的RNA剪接和细胞凋亡中发挥作用。这种蛋白还参与剪接因子RNA结合基序蛋白39 (RBM39) 的泛素化和降解。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
Jin J, et al.
Molecular Cell, 23(5), 709-721 (2006)
Expanding the spectrum of rearrangements involving chromosome 19: A mild phenotype associated with a 19p13.12-p13. 13 deletion
Marangi G, et al.
American Journal of Medical Genetics. Part A, 158(4), 888-893 (2012)
Xiao Dong et al.
Aging, 13(7), 10603-10618 (2021-04-10)
Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved developmental program that has been implicated in tumorigenesis and confers metastatic properties upon cancer cells. ZEB1 is a master transcription factor that activates the EMT process in various cancers. ZEB1 is reportedly degraded
Tabitha C Ting et al.
Cell reports, 29(6), 1499-1510 (2019-11-07)
Indisulam and related sulfonamides recruit the splicing factor RBM39 to the CRL4-DCAF15 E3 ubiquitin ligase, resulting in RBM39 ubiquitination and degradation. Here, we used a combination of domain mapping and random mutagenesis to identify domains or residues that are necessary
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