Merck
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安全信息

SAB1300717

Sigma-Aldrich

Anti-CDA (center) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

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别名:
Anti-CDD, Anti-Cytidine aminohydrolase, Anti-Cytidine deaminase
NACRES:
NA.41

生物来源

rabbit

质量水平

100

偶联物

unconjugated

抗体形式

saturated ammonium sulfate (SAS) precipitated

antibody product type

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

species reactivity

mouse, human

technique(s)

indirect ELISA: 1:1000
western blot: 1:100-1:500

NCBI登记号

NP_001776

UniProt登记号

P32320

运输

dry ice

储存温度

−20°C

target post-translational modification

unmodified

Gene Information

human ... CDA(978)

一般描述

CDA forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. This protein is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in the CDA gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

免疫原

CDA (NP_001776, 55-93)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human CDA.

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)

外形

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Yan Zhao et al.
Oncology letters, 20(5), 247-247 (2020-09-26)
The development of drug resistance to chemotherapeutic agents has consistently presented a challenge in terms of the treatment of patients with triple-negative breast cancer (TNBC). In the present study, gemcitabine (dFdC)-resistant TNBC cells were established, and the effects of lentivirus-deoxyribonucleoside
Melania Zauri et al.
Nature, 524(7563), 114-118 (2015-07-23)
Cells require nucleotides to support DNA replication and repair damaged DNA. In addition to de novo synthesis, cells recycle nucleotides from the DNA of dying cells or from cellular material ingested through the diet. Salvaged nucleosides come with the complication
Haejeong Heo et al.
Experimental & molecular medicine, 54(8), 1236-1249 (2022-08-24)
Acquired resistance to inhibitors of anaplastic lymphoma kinase (ALK) is a major clinical challenge for ALK fusion-positive non-small-cell lung cancer (NSCLC). In the absence of secondary ALK mutations, epigenetic reprogramming is one of the main mechanisms of drug resistance, as

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