ATAD3A (ATPase family, AAA domain containing 3A) is mapped to human chromosome 1p36.33. The encoded protein is a localized in mitochondrial membrane.

ATAD3A (AAH33109.1, 1 a.a. ~ 586 a.a) full-length human protein.

Sequence
MSWLFGINKGPKGEGAGPPPPLPPAQPGAEGGGDRGLGDRPAPKDKWSNFDPTGLERAAKAARELEHSRYAKDALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRKTLSEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGVLTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS

ATAD3A (ATPase family, AAA domain containing 3A) was originally considered as a tumor-specific antigen. Mutation in ATAD3A is known to cause a delayed development, optic atrophy, axonal neuropathy, hypotonia and hypertrophic cardiomyopathy. ATAD3A is involved in mitochondrial development, organization of nucleoid, translation of protein, cell growth, and cholesterol metabolism. Downregulation of ATAD3A affects the mitochondrial dynamics, prevents proliferation and changes the interaction between mitochondria and the endoplasmic reticulum. Upregulation of the gene is seen in several cancer types. ATAD3A is known to offer resistance against chemotherapy and radiation. It is responsible for the mitochondrial membrane and import vesicle -mediated transport of AIF (apoptosis inducing factor) from the endoplasmic reticulum into mitochondria. Downregulation of ATAD3A promotes autophagy as well as apoptosis in uterine cervical cancer cells, and also reduces the ability to resist the anticancer drugs. ATAD3A serves as a biomarker for the prognosis of glioblastoma multiforme. It is also found to be involved in cancers such as uterine cervical cancer, lung adenocarcinoma and prostate cancer.

Solution in phosphate buffered saline, pH 7.4

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