SAB1402692
Monoclonal Anti-APOC3, (C-terminal) antibody produced in mouse
clone 8H7, purified immunoglobulin, buffered aqueous solution
别名:
APOCIII, MGC150353
产品名称
Monoclonal Anti-APOC3, (C-terminal) antibody produced in mouse, clone 8H7, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
8H7, monoclonal
form
buffered aqueous solution
mol wt
antigen ~34.8 kDa
species reactivity
human
technique(s)
immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APOC3(345)
Biochem/physiol Actions
Apolipoprotein C3 (APOC3) is involved in the metabolism of triglyceride-rich lipoproteins. It may have a role in atherosclerosis. The protein stimulates hypertriglyceridemia (HTG) by inhibiting the activity of lipoprotein lipase and interfering with the binding of APOB or APOE to hepatic receptors. It also promotes very low density lipoprotein (VLDL) assembly and secretion in the liver.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Apolipoprotein C3 (APOC3) is a 79 amino acid protein with a molecular weight of 8.8kDa. It is present on high density, low density and triglyceride-rich lipoproteins. The gene encoding this protein is localized on human chromosome 11q23.3.
Immunogen
APOC3 (NP_000031.1, 21 a.a. ~ 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA
Sequence
SEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA
Physical form
Solution in phosphate buffered saline, pH 7.4
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The emerging role of apolipoprotein C-III: beyond effects on triglyceride metabolism.
Luo M and Peng D
Liposome Technology (2016)
Variants in the APOC3 promoter insulin responsive element modulate insulin secretion and lipids in middle-aged men
D. M> Waterworth
Biochim. Biophys. Acta Gen. Subj. (2003)
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