SAB1409988
Monoclonal Anti-PTTG1 antibody produced in mouse
clone 3F9, purified immunoglobulin, buffered aqueous solution
别名:
EAP1, HPTTG, MGC126883, MGC138276, PTTG, TUTR1
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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
3F9, monoclonal
Application:
immunofluorescence
indirect ELISA
indirect ELISA
Species reactivity:
human
Citations:
Technique(s):
immunofluorescence: suitable
indirect ELISA: suitable
indirect ELISA: suitable
Uniprot accession no.:
产品名称
Monoclonal Anti-PTTG1 antibody produced in mouse, clone 3F9, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3F9, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable
indirect ELISA: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PTTG1(9232)
General description
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. (provided by RefSeq)
Immunogen
PTTG1 (NP_004210, 93 a.a. ~ 113 a.a) synthetic peptide.
Sequence
MTEKTVKAKSSVPASDDAYPE
Sequence
MTEKTVKAKSSVPASDDAYPE
Physical form
Solution in phosphate buffered saline, pH 7.4
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
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