产品名称
Anti-NUDT16L1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
23 kDa
species reactivity
mouse, dog, rat, human, bovine, guinea pig, rabbit
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NUDT16L1(84309)
Biochem/physiol Actions
Nudix hydrolase 16 like 1 (NUDT16L1) repairs double strand breaks by masking the histone methyl-lysine binding function of P53 binding protein 1 (53BP1). NUDT16L1 acts as an inhibitor of 53BP1.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Nudix hydrolase 16 like 1 (NUDT16L1) protein belongs to a nucleoside diphosphate-linked moiety X (Nudix) hydrolases family. It is also known as TIRR (tudor interacting repair regulator), which specifically interacts with the ionizing radiation induced foci formation (IRIF) region of P53 binding protein 1 (53BP1). NUDT16L1 gene is located on human chromosome 16p13.3.
Immunogen
Synthetic peptide directed towards the middle region of human NUDT16L1
Other Notes
Synthetic peptide located within the following region: LNRVLGLGLGCLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEI
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The p53-binding protein 1-Tudor interacting repair regulator complex participates in the DNA damage response
Zhang A, et al.
The Journal of Biological Chemistry, jbc-M117 (2017)
The Nudix hydrolase superfamily
McLennan AG, et al.
Cellular and Molecular Life Sciences, 63(2), lp9l9l-lp9l9l (2006)
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function
Drane P et al.
Nature, 543(7644), 211-211 (2017)
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