SAB2500431
Anti-FTL antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Ferritin L subunit, Anti-L apoferritin, Anti-MGC71996
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IHC, WB
Citations:
10
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
technique(s)
immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FTL(2512)
General description
Ferritin light (FTL) subunit along with ferritin heavy (FTH) subunit are members of the ferritin complex. FTL gene is mapped on the human chromosome at 19q13.33.
Immunogen
Peptide with sequence C-GEYLFERLTLKHD from the C Terminus of the protein sequence according to NP_000137.2.
Application
Anti-FTL antibody produced in goat has been used in western blotting (1:500).
Biochem/physiol Actions
Ferritin light (FTL) subunit is an important protein in iron metabolism but lacks catalytic activity. This protein participates in the nucleation and mineralization of the iron center. FTL acts as a biomarker to differentiate between malignant and benign tumors. Overexpression of the FTL gene is observed in several malignant tumors and plays an important role in mediating the malignancy of cancers. FTL gene plays a role in the pathogenesis of glioblastoma. Mutation or deletion of the FTL gene is associated with neuroferritinopathy.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sara Zumerle et al.
Blood, 123(23), 3646-3650 (2014-03-22)
Hepcidin is a 25-amino-acid peptide demonstrated to be the iron regulatory hormone capable of blocking iron absorption from the duodenum and iron release from macrophages. Mutations affecting hepcidin regulators or the hepcidin gene itself cause hemochromatosis, a common genetic disorder.
Junhui Liu et al.
Journal of experimental & clinical cancer research : CR, 39(1), 137-137 (2020-07-18)
Hypoxia, a fundamental characteristic of glioma, is considered to promote tumor malignancy by inducing process of epithelial mesenchymal transition (EMT). Ferritin Light Chain (FTL) is one of the iron metabolism regulators and is overexpressed in glioma. However, relationship between hypoxia
Mimi C Sammarco et al.
The Journal of biological chemistry, 283(8), 4578-4587 (2007-12-28)
Ferritin plays an important role in the storage and release of iron, an element utilized in cellular processes such as respiration, gene regulation, and DNA replication and repair. Ferritin in animals is composed of 24 ferritin L (FTL) and ferritin
Jean-Christophe Deschemin et al.
Frontiers in physiology, 8, 804-804 (2017-11-02)
Pulmonary iron excess is deleterious and contributes to a range of chronic and acute inflammatory diseases. Optimal lung iron concentration is maintained through dynamic regulation of iron transport and storage proteins. The iron-regulatory hormone hepcidin is also expressed in the
Jean-Christophe Deschemin et al.
PloS one, 10(12), e0145685-e0145685 (2015-12-29)
Cystic Fibrosis (CF) is a frequent and lethal autosomal recessive disease caused by mutations in the gene encoding the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Patients with CF suffer from chronic infections and severe inflammation, which lead to progressive pulmonary
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