SAB2500747
Anti-Pancreatic polypeptide/PPY antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-HGNC:9327, Anti-PNP
产品名称
Anti-Pancreatic polypeptide/PPY antibody produced in goat, affinity isolated antibody, buffered aqueous solution
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PPY(5539)
Application
Anti-Pancreatic polypeptide/PPY antibody produced in goat has been used in immunohistochemistry and immunofluorescence.
Biochem/physiol Actions
Pancreatic polypeptide (PPY) or PP has glucoregulatory functions. It modulates biliary secretion and food digestion by preventing gastric emptying. PPY binds to the Y4 receptor and has a role in increasing the number of insulin receptors on hepatocytes. The protein has been associated with chronic pancreatitis and pancreatogenic diabetes. PPY also negatively regulates the expression of resistin hormone.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Pancreatic polypeptide (PPY) or PP is an endogenous peptide hormone. It is secreted by the PP cells of the Islets of Langerhans, in the pancreas. PPY is part of the neuropeptide Y family of hormones. It is a 36 amino acid proteinand the gene encoding it is localized on human chromosome 17q21.31.
Immunogen
Peptide with sequence C-TRPRYGKRHKEDT from the internal region of the protein sequence according to NP_002713.1.
Physical form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
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存储类别
10 - Combustible liquids
wgk
WGK 2
法规信息
常规特殊物品
此项目有
Chuan He et al.
Journal of anatomy, 226(4), 373-380 (2015-02-17)
Monotremes have undergone remarkable changes to their digestive and metabolic control system; however, the monotreme pancreas remains poorly characterized. Previous work in echidna demonstrated the presence of pancreatic islets, but no information is available for platypus and the fine structure
Human pancreatic polypeptide in a phospholipid-based micellar formulation.
Banerjee A and Onyuksel H
Pharmaceutical Research, 29(6), 1678-1711 (2012)
Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding.
Lerch M, et al.
Biochemistry (2005)
Immunohistochemical analysis of pancreatic islets of platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus ssp.)
Chuan He, et al.
Journal of Anatomy (2015)
CXCL14-Like Immunoreactivity Exists in Somatostatin-Containing Cells of Mouse Pancreas
Hirohumi Suzuki, Toshiharu Yamamoto
Acta Histochemica Et Cytochemica (2015)
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