SAB2501506
Anti-ZCCHC11 (C-terminal) antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-KIAA0191, Anti-bHLHa22, CCHC domain containing 11, PAP associated domain containing 3, Zinc finger
生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
canine, bovine, human, rat, mouse
技术
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ZCCHC11(23318)
一般描述
Zinc finger CCHC-type containing 11 (ZCCHC11) is a 3′ terminal uridylyl transferase. It possesses multiple domains and has a molecular weight of about 185kDa. A fragment of the protein contains a TRF4 domain, a nucleotidyl transferase domain (NTD), two PAP-associated domains and three zinc finger domains. The ZCCHC11 gene is localized on human chromosome 1p32.3.
免疫原
Peptide with sequence RERCPHPPRGNVSE, from the C-terminal region of the protein sequence according to NP_001009881.1; NP_056084.1; NP_001009882.1
生化/生理作用
Zinc finger CCHC-type containing 11 (ZCCHC11) has a role in the RNA-binding protein Lin28 blockade of let-7 microRNA biogenesis. It is recruited by Lin28 to pre-let-7 (let-7 precursors), where it catalyzes the addition of an oligo (U)-tail.The protein is crucial for poly (A) tail length maintenance. ZCCHC11 also has a role in regulating the stability of transcripts for interleukin-6 and other cytokines.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Molecular similarity between myelodysplastic form of chronic
myelomonocytic leukemia and refractory anemia with ring
sideroblasts
myelomonocytic leukemia and refractory anemia with ring
sideroblasts
Veronique Gelsi-Boyer
Haematologica (2012)
Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Jones MR, et.al
Nature Cell Biology, 11(9), 1157-1163 (2009)
Identification of small molecule inhibitors of Zcchc11 TUTase activity.
Lin S and Gregory RI
RNA Biology, 12(8), 792-800 (2015)
Matthew R Jones et al.
Nature cell biology, 11(9), 1157-1163 (2009-08-25)
Mounting an effective host immune response without incurring inflammatory injury requires the precise regulation of cytokine expression. To achieve this, cytokine mRNAs are post-transcriptionally regulated by diverse RNA-binding proteins and microRNAs (miRNAs) targeting their 3' untranslated regions (UTRs). Zcchc11 (zinc-finger
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