biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
liquid
mol wt
69 kDa
species reactivity
mouse, human, rat
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:1,000
western blot: 1:500-1:3,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... DBH(1621)
Application
Anti-DBH antibody produced in rabbit has been used in immunohistochemistry (1:200) (1:1000).
Biochem/physiol Actions
Dopamine-β-hydroxylase (DBH) protein plays a role in the conversion of dopamine to noradrenaline. This protein is implicated in various disorders such as Huntington′s chorea, hypertension, Parkinson′s, and smoking disorders. DBH protein is also implicated in heart failure and mental disorders like depression, Tourette syndrome, and schizophrenia. Lower levels of DHB plasma are seen in patients with bipolar disorders and unipolar psychotic depression. Higher levels of DBH plasma are observed in patients with severe depression.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Dopamine-β-hydroxylase (DBH) is found in the nuclei of noradrenergic and dopaminergic neurons. The DBH gene is mapped on the human chromosome at 9q34.2.
Immunogen
Recombinant fragment corresponding to a region within amino acids 8 and 320 of Dopamine beta Hydroxylase (Uniprot ID#P09172)
Physical form
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Skin Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Shuang Zhang et al.
Journal of neuroscience research, 94(10), 896-906 (2016-06-19)
Rett syndrome (RTT) is a neurodevelopmental disorder affecting multiple functions, including the norepinephrine (NE) system. In the CNS, NE is produced mostly by neurons in the locus coeruleus (LC), where defects in intrinsic neuronal properties, NE biosynthetic enzymes, neuronal CO2
Yao Liu et al.
Experimental physiology, 102(8), 974-984 (2017-06-08)
What is the central question of this study? We investigated the effects of oestrogen and Cimicifuga racemosa on the stellate ganglion, cardiac noradrenaline pathway and Ca2+ -calmodulin-dependent protein kinase II in ovariectomized rats. What is the main finding and its
U W Preuss et al.
Drug and alcohol dependence, 133(2), 459-467 (2013-08-03)
Dopamine-beta-hydroxylase (DBH) metabolizes the conversion of dopamine to noradrenaline. DBH, located on chromosome 9q34.2 has variants with potential functional consequences which may be related to alterations of neurotransmitter function and several psychiatric phenotypes, including alcohol dependence (AD), depression (MD) and
Marci F Rosenberg et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(50), 8621-8636 (2023-10-17)
Astrocytes play essential roles in the developing nervous system, including supporting synapse function. These astrocyte support functions emerge coincident with brain maturation and may be tailored in a region-specific manner. For example, gray matter astrocytes have elaborate synapse-associated processes and
Elizabeth S Bucher et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(7), 1128-1137 (2014-04-10)
Neurovascular coupling is understood to be the underlying mechanism of functional hyperemia, but the actions of the neurotransmitters involved are not well characterized. Here we investigate the local role of the neurotransmitter norepinephrine in the ventral bed nucleus of the
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