SAB3500315
Anti-TRIAD3A antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 95 kDa
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... RNF216(54476)
General description
Ring finger protein 216 (RNF216) is an E3 ubiquitin ligase. The gene encoding this protein is localized on human chromosome 7p22.3.
Immunogen
TRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.
Biochem/physiol Actions
Ring finger protein 216 (RNF216) associates with toll-like receptors and aids in their degradation. It also aids in the degradation of receptor interacting protein-1 (RIP-1) kinase and negatively modulates tumor necrosis α receptor signaling. The protein acts as an inhibitor of autophagy in macrophages. Mutations in the RNF216 gene have been associated with Gordon Holmes syndrome.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500315.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination.
Xu C
Autophagy (2014)
Ubiquitylation of an internalized killer cell Ig-like receptor by Triad3A disrupts sustained NF-?B signaling.
Miah SM
Journal of Immunology (2011)
RNF216 mutations as a novel cause of autosomal recessive Huntington-like disorder.
Santens P
Neurology (2015)
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