SAB3500395
抗-PDL-2 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
抗-B7DC, 抗-PD-L2, 抗-细胞程序性死亡 1, 抗-细胞程序性死亡1配体-2
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunofluorescence
immunohistochemistry
indirect ELISA
western blot
immunohistochemistry
indirect ELISA
western blot
Species reactivity:
human, rat, mouse
Citations:
11
Technique(s):
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-PDL-2 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 30 kDa
species reactivity
human, rat, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PDCD1LG2(80380)
Application
兔抗-PDL-2 抗体可用于免疫组化。
Biochem/physiol Actions
程序性细胞死亡1配体2（PD-L2）或CD抗原273（CD273）的表达会通过干扰素-γ（IFNG /IFN-γ）刺激在单核细胞中上调，并在由外周血单核细胞生长而来的树突状细胞中，可通过集落刺激因子2（CSF2）和白介素4（IL-4）进行诱导。PD-L2参与共刺激信号，这对T细胞以不依赖PDCD1的方式增殖和产生IFNG至关重要。PD-L2与PDCD1的相互作用可通过阻止细胞周期进程和细胞因子产生而抑制T细胞增殖。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
General description
程序性细胞死亡1配体2（PD-L2或PDCD1配体2）也称为嗜丁菌素B7-DC或CD273。它属于免疫球蛋白超家族。编码PDL-2的基因位于人类染色体9p24.1上。
Immunogen
PDL-2抗体通过靶向人PDL-2中心附近的16个氨基酸多肽产生。
Other Notes
可以使用阻断肽 SBP3500395阻断该抗体的作用。
Physical form
以含有 0.02% 叠氮化钠的 PBS 形式提供。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
PD-L2:PD-1 involvement in T cell proliferation,
cytokine production, and integrin-mediated adhesion
cytokine production, and integrin-mediated adhesion
Paul A. Saunders
European Journal of Immunology (2005)
Konstantinos Georgiou et al.
Blood, 127(24), 3026-3034 (2016-04-01)
Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using
Expression of PD-1, PD-L1 and PD-L2 is associated with differentiation status and histological type of endometrial cancer
Zhongfu Mo
Oncology Letters (2016)
Misung Yi et al.
BMC bioinformatics, 24(1), 298-298 (2023-07-23)
Protein biomarkers of cancer progression and response to therapy are increasingly important for improving personalized medicine. Advanced quantitative pathology platforms enable measurement of protein expression in tissues at the single-cell level. However, this rich quantitative cell-by-cell biomarker information is most
Carlo Sorrentino et al.
Frontiers in immunology, 12, 778329-778329 (2022-01-04)
Colorectal cancer (CRC) is one of the most common cancer worldwide, with a growing impact on public health and clinical management. Immunotherapy has shown promise in the treatment of advanced cancers, but needs to be improved for CRC, since only
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