SAB3500723
Anti-TM4SF1 antibody produced in rabbit
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
western blot
Species reactivity:
rat, human, mouse
Citations:
6
Technique(s):
ELISA: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-TM4SF1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
mol wt
22 kDa
species reactivity
rat, human, mouse
concentration
1 mg/mL
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TM4SF1(4071)
Biochem/physiol Actions
Transmembrane 4 L6 family member 1 (TM4SF1) has a novel function in androgen receptor (AR) signaling. Its mRNA expression is higher in prostate cancer tissues as compared to benign prostatic hyperplasia (BPH). It is found to contribute to prostate cancer cell metastasis. The TM4SF1 gene serves as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins. It uniquely initiates the formation of nanopodia and facilitates cell polarization and migration. TM4SF1 also regulates tumor cell motility and invasiveness. It is abundant on the plasma membrane and on intracellular vesicles.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Transmembrane 4 L6 family member 1 (TM4SF1) is a protein encoded by the TM4SF1 gene in humans. It is a cell surface antigen, which is highly expressed in lung, breast, colon and ovarian carcinomas. The TM4SF1 gene is localized on human chromosome 3q25.1.
Immunogen
Antibody was raised against an 18 amino acid peptide near the amino terminus of human TM4SF1.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500723.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
he tumour-associated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: implication for tumour cell motility
Journal of Cell Science (2008)
TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration
Andrew Zukauskas
Angiogenesis, 14 (2011)
TM4SF1, a novel primary androgen receptor target gene over-expressed in human prostate cancer and involved in cell migration
Prostate, 71 (2011)
KARE Genomewide Association Study of Blood Pressure
Using Imputed SNPs
Using Imputed SNPs
Kyung-Won Hong
Genomics & informatics, 103-107 (2010)
Cloning and expression of the tumor-associated antigen L6
J S Marken
Proceedings of the National Academy of Sciences of the USA, 89 (1992)
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