SAB4200023
Anti-VPS4B antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-SKD1, Anti-SKD1-homolog, Anti-SKD1A, Anti-SKD2, Anti-VPS4, Anti-VPS4-1, Anti-Vacuolar protein sorting 4 homolog A, Anti-Vacuolar protein sorting factor 4A
产品名称
Anti-VPS4B antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human, mouse
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 10-20 μg using lysate of mouse 3T3 cells
western blot: 2-4 μg/mL using whole extracts of G361 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... VPS4B(9525)
Application
Anti-VPS4B antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Vacuolar protein sorting 4 (Vps4) mediates endosomal membrane protein sorting, retroviral budding, and cytokinesis by recognizing membrane-associated endosomal sorting complexes required for transport (ESCRT-III) assemblies and catalysing their disassembly.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Vacuolar protein sorting 4 homolog B (Vps4B) is a member of the AAA protein family (ATPases associated with diverse cellular activities) and is a homolog of yeast Vps4 protein. In humans, two of yeast protein paralogs have been identified as Vps4A and Vps4B. Both share high degree of amino acid sequence. The gene for Vps4B resides on human chromosome 18.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Luana L Scheffer et al.
Nature communications, 5, 5646-5646 (2014-12-24)
In muscle and other mechanically active tissue, cell membranes are constantly injured, and their repair depends on the injury-induced increase in cytosolic calcium. Here, we show that injury-triggered Ca(2+) increase results in assembly of ESCRT III and accessory proteins at
Comparative sequence and expression analyses of four mammalian VPS4 genes
Beyer A, et al.
Gene, 305(1), 47-59 (2003)
Membrane scission by the ESCRT-III complex
Wollert T, et al.
Nature, 458(7235), 172-172 (2009)
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