SAB4200106
Anti-ULK1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-ATG1 autophagy related 1 homolog, Anti-UNC51, Anti-Unc51.1, Anti-unc-51-like kinase 1
产品名称
Anti-ULK1 antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~150 kDa
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
western blot: 1-2 μg/mL using whole extracts of HEK-293T cells overexpressing human ULK1.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ULK1(8408)
Application
Anti-ULK1 has been used in immunoblotting.
Biochem/physiol Actions
Anti-ULK1 recognizes human ULK1.
Uncoordinated 51-like kinase 1 (ULK1) is involved in modulating Atg9 subcellular dynamics. Knockdown of ULK1, but not ULK2, inhibits the autophagic response. Overexpression of ULK1 also inhibits autophagy, suggesting that ULK1 may have multiple mechanisms for regulating autophagy. Knockdown of Ulk1 shRNA can prevent gastric cancer cell survival.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Uncoordinated 51-like kinase 1 (ULK1) is expressed in skeletal muscle, heart, pancreas, brain, placenta, liver, kidney and lung. This gene is located on human chromosome 2q24.3. ULK1 localizes to cytoplasmic structures. ULK1 and ULK2 is a homolog of autophagy related 1 (Atg1) gene.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
Chan EYW, et al.
The Journal of Biological Chemistry, 282(35), 25464-25474 (2007)
Ulk1 over-expression in human gastric cancer is correlated with patients' T classification and cancer relapse
Chen MB, et al.
Testing, 8(20), 33704-33704 (2017)
Gemcitabine induces poly (ADP-ribose) polymerase-1 (PARP-1) degradation through autophagy in pancreatic cancer
Wang Y, et al.
PLoS ONE, 9(10), e109076-e109076 (2014)
Human ULK1, a Novel Serine/Threonine Kinase Related to UNC-51 Kinase ofCaenorhabditis elegans: cDNA Cloning, Expression, and Chromosomal Assignment
Kuroyanagi H, et al.
Genomics, 51(1), 76-85 (1998)
Xin Yu et al.
Journal of molecular neuroscience : MN, 50(3), 586-599 (2013-04-18)
Spinocerebellar ataxia type 7 (SCA7) is one of nine neurodegenerative disorders caused by expanded polyglutamine domains. These so-called polyglutamine (polyQ) diseases are all characterized by aggregation. Reducing the level of aggregating polyQ proteins via pharmacological activation of autophagy has been
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