SAB4200201
Anti-Cyclophilin B antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-CYP-S1, Anti-CYPB, Anti-OI9, Anti-PPIB, Anti-PPIase B, Anti-S-cyclophilin, Anti-SCYLP, Anti-cyclophilin-like protein, Anti-peptidyl-prolyl cis-trans isomerase B, Anti-peptidylprolyl isomerase B, Anti-rotamase B
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
indirect immunofluorescence
western blot
western blot
Species reactivity:
human, rat, monkey, mouse
Citations:
9
Technique(s):
indirect immunofluorescence: 5-10 μg/mL using mouse 3T3 cells
western blot: 0.5-1.0 μg/mL using whole extracts of human HepG2 and rat NRK cells
western blot: 0.5-1.0 μg/mL using whole extracts of human HepG2 and rat NRK cells
Uniprot accession no.:
产品名称
Anti-Cyclophilin B antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~20 kDa
species reactivity
human, rat, monkey, mouse
enhanced validation
independent
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using mouse 3T3 cells
western blot: 0.5-1.0 μg/mL using whole extracts of human HepG2 and rat NRK cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PPIB(5479)
mouse ... Ppib(19035)
Application
Anti-Cyclophilin B antibody produced in rabbit has been used:
- immunoblotting
- immunofluorescence
- in immunocapture-polymerase chain reaction (PCR) to study the interactions between CypB and Tomato yellow leaf curl virus (TYLCV) coat protein (CP).
Biochem/physiol Actions
Cyclophilins are peptidyl-prolyl cistrans isomerases (PPIases) that assist protein folding by catalysing the isomerization of peptidyl-proline bonds. Cyclophilin B (CypB) also plays an important role in protecting cells against ER stress via its PPIase activity. Mutations in the PPIB gene give rise to recessive forms of osteogenesis imperfecta and knockdown of this gene decreases cell growth, proliferation and migration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Anti-Cyclophilin B is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human Cyclophilin B conjugated to KLH. Cyclophilin B (CypB) is a 21 kDa protein encoded by the PPIB gene, that belongs to the cyclophilin family, a highly conserved class of proteins originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. CypB is mainly located within the endoplasmic reticulum (ER) of all cell types. CypB is involved in inflammation, viral infection and cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress
Kim J, et al.
Journal of Cell Science, 121(21), 3636-3648 (2008)
Surapathrudu Kanakala et al.
Frontiers in plant science, 7, 1702-1702 (2016-11-30)
Tomato yellow leaf curl virus (TYLCV) is a single-stranded (ssDNA) begomoviruses that causes severe damage to tomato and several other crops worldwide. TYLCV is exclusively transmitted by the sweetpotato whitefly, Bemisia tabaci in a persistent circulative and propagative manner. Previous
Severe osteogenesis imperfecta in cyclophilin B-deficient mice
Choi JW, et al.
PLoS Genetics, 5(12), e1000750-e1000750 (2009)
Implication of the whitefly Bemisia tabaci cyclophilin B protein in the transmission of Tomato yellow leaf curl virus
Kanakala S and Ghanim M
Frontiers in Plant Science, 7, 1702-1702 (2016)
Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer
Fang F, et al.
The American Journal of Pathology, 174(1), 297-308 (2009)
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