SAB4200215
Anti-VPS4A antibody, Mouse monoclonal
clone VPS4-110, purified from hybridoma cell culture
别名:
Anti-SKD1, SKD1A, SKD2, VPS4-1, Anti-Vacuolar protein sorting factor 4A, Anti-hVPS4
产品名称
Anti-VPS4A antibody, Mouse monoclonal, clone VPS4-110, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
VPS4-110, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
mouse, canine, bovine, human, rat
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or human HEK-293 cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... VPS4A(27183)
mouse ... Vps4a(116733)
rat ... Vps4a(246772)
Application
Monoclonal Anti-VPS4A antibody has been used in
- immunoblotting
- immunoprecipitation
- immunolabelling
Biochem/physiol Actions
Vacuolar-protein-sorting factor 4A (VPS4A) plays a vital role in lysosomal/endosomal membrane trafficking. It is also involved in the regulation of exosome biogenesis. Downregulated expression of the gene leads to the development of hepatocellular carcinoma (HCC). Thus, VPS4 is considered to be an effective tumor suppressor for HCC. Mutation of the gene leads to defective multivesicular body formation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-VPS4A (mouse IgG1 isotype) is derived from the hybridoma VPS4-110 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human VPS4A, conjugated to KLH.
Vacuolar-protein-sorting factor 4A (VPS4A) is an AAAtype ATPase, encoded by the gene mapped to human chromosome 16q22.1. The encoded protein is a member of vacuolar sorting protein family. The protein is characterized by a canonical AAA ATPase cassette followed by an N-terminal MIT (microtubule interacting and trafficking) domain.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
Comparative sequence and expression analyses of four mammalian VPS4 genes
Beyer A
Gene, 305, 47-59 (2003)
Triggered recruitment of ESCRT machinery promotes endolysosomal repair
Skowyra M L, et al.
Science, 360(6384), eaar5078-eaar5078 (2018)
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A
Scott A
Proceedings of the National Academy of Sciences of the USA, 102, 13813-13818 (2005)
A fourth locus for autosomal dominant hypercholesterolemia maps at 16q22.1
Marques-Pinheiro A
European Journal of Human Genetics, 18, 1236-1242 (2010)
Disruption of Neurexin 1 Associated with Autism Spectrum Disorder
Kim HG
American Journal of Human Genetics, 82, 199-207 (2008)
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