SAB4200311
抗-O-GlcNAcase (OGA) (C端区域) 兔抗
~1.5 mg/mL, affinity isolated antibody
别名:
抗- N-乙酰基-beta-D-氨基葡萄糖苷酶, 抗- N-乙酰基-beta-氨基葡萄糖苷酶, 抗-Beta-N-乙酰基己糖胺酶, 抗-MEA5, 抗-NCOAT, 抗-O-GlcNAcase酶, 抗-OGA, 抗-己糖胺酶C, 抗-脑膜瘤表达抗原5（透明质酸酶）
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
western blot
western blot
Species reactivity:
canine, human
Citations:
19
Technique(s):
immunoprecipitation (IP): 3-6 μg using MDCK cells.
western blot: 2-4 μg/mL using MCF7 cell extracts.
western blot: 2-4 μg/mL using MCF7 cell extracts.
Uniprot accession no.:
产品名称
抗-O-GlcNAcase (OGA) (C端区域) 兔抗, ~1.5 mg/mL, affinity isolated antibody
conjugate
unconjugated
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~130 kDa
species reactivity
canine, human
concentration
~1.5 mg/mL
technique(s)
immunoprecipitation (IP): 3-6 μg using MDCK cells.
western blot: 2-4 μg/mL using MCF7 cell extracts.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MGEA5(10724)
Biochem/physiol Actions
β-N-乙酰氨基葡萄糖苷酶（OGA）以及O-GlcNAc转移酶（OGT）是可调节循环中的O-连接N-乙酰葡糖胺的关键酶。OGA负责将靶蛋白中的修饰进行断裂。OGA也是被OGT糖基化的，并在这两种酶之间存在有一个调节反馈环。在与组蛋去乙酰化酶（HDAC）形成的转录共抑制复合物中，OGA和OGT是紧密结合在一起的。
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除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
General description
β-N-乙酰氨基葡萄糖苷酶（OGA）基因编码了两种在哺乳动物组织中广泛表达的可变剪接异构体。OGA（也称为 O-GlcNAcase、MGEA5、NCOAT）属于84糖苷水解酶家族。较长的OGA形式是一种包含两个不同结构域的双功能核/细胞质酶，即位于N端的O-GlcNAcase结构域和位于C端的假定组蛋白乙酰转移酶（HAT）结构域。较短的OGA形式仅含有N端的O-GlcNAcase结构域。
Immunogen
该合成肽与KLH偶联，其对应于人O-GlcNAc酶(OGA)C末端附近的序列。相应的序列在人OGA同工型B中相同，并且在大鼠和小鼠OGA中高度保守（单个氨基酸取代）。
Physical form
0.01M磷酸盐缓冲盐水溶液，pH 7.4，含有15 mM叠氮化钠。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Changes in O-linked N-acetylglucosamine (O-GlcNAc) homeostasis activate the p53 pathway in ovarian cancer cells
de Queiroz RM, et al.
The Journal of Biological Chemistry, 291(36), 18897-18914 (2016)
Hexosamine Biosynthetic Pathway and Glycosylation Regulate Cell Migration in Melanoma Cells
de Queiroz RM, et al.
Frontiers in Oncology, 9 (2019)
Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival
Rauth M, et al.
International Journal of Molecular Sciences, 20(5), 1028-1028 (2019)
Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription
Groussaud D, et al.
PLoS Pathogens, 13(7), e1006518-e1006518 (2017)
Paweł Jóźwiak et al.
Cancers, 13(12) (2021-07-03)
O-GlcNAcylation is a cell glucose sensor. The addition of O-GlcNAc moieties to target protein is catalyzed by the O-Linked N-acetylglucosamine transferase (OGT). OGT is encoded by a single gene that yields differentially spliced OGT isoforms. One of them is targeted
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