SAB4200361
Anti-MAP1LC3B Antibody
mouse monoclonal, LC3B-6
别名:
单克隆抗-ATG8F, 单克隆抗-LC3, 单克隆抗-MAP1A/1BLC3, 单克隆抗-MAP1LC3B, 单克隆抗-微管相关蛋白1轻链3β
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.43
Conjugate:
unconjugated
Clone:
LC3B-6, monoclonal
Application:
IP, WB
Citations:
18
产品名称
抗-LC3B抗体，小鼠单克隆, clone LC3B-6, purified from hybridoma cell culture
Quality Level
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
LC3B-6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~18/16 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 10-20 μg using lysates of human U-87 cells., western blot: 1-2 μg/mL using whole extracts of HEK-293T cells over-expressing human LC3B.
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAP1LC3B(81631)
General description
MAP1LC3B基因（微管相关蛋白1轻链3β）是酵母中的自噬相关基因ATG8的一种同源基因。编码的蛋白质称为pro-MAP1LC3B，这是一种被ATG4裂解以产生MAP1LC3B-1胞浆形式的前体形式。 小鼠单克隆抗LC3B抗体（小鼠IgG2b同种型）来源于LC3B-6杂交瘤，该杂交瘤是由小鼠骨髓瘤细胞与用对应于人LC3B N末端区域的合成肽免疫的BALB / c小鼠脾细胞融合产生。
Immunogen
对应于人LC3B的N-末端区域的合成肽，与KLH耦合。相应的序列在大鼠和小鼠中相差一个氨基酸。
Biochem/physiol Actions
在自噬过程中被插入至生长中的自噬囊泡的内膜和外膜前，MAP1LC3B-I（微管相关蛋白1轻链3β-I）会结合MAP1LC3B-II。MAP1LC3B的细胞分布和加工有助于对自噬进行监测。缺乏MAP1LC3B的细胞被发现在自噬囊泡的形成中存在缺陷，其改变的表型与自噬在能量稳态和蛋白聚集体去除中的作用相关。它可作为一种自噬的标志物。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200361-200UL | 04061838036087 |