SAB4200465
Anti-Kindlin-1 antibody, Mouse monoclonal
clone KN-4, purified from hybridoma cell culture
别名:
Monoclonal Anti-C20orf42, Monoclonal Anti-DTGCU2, Monoclonal Anti-FERMT1 URP1, Monoclonal Anti-KIND1, Monoclonal Anti-Kindlin-1 antibody produced in mouse, Monoclonal Anti-UNC112A, Monoclonal Anti-fermitin family member 1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
KN-4, monoclonal
Application:
IF, WB
Citations:
9
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
KN-4, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa (isoform 4), antigen ~60 kDa (isoform 2), antigen ~77 kDa (isoform 1)
species reactivity
mouse, human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 2.5-5.0 μg/mL using SW-620 cells, western blot: 1.0-2.0 μg/mL using SW-48 total cell extracts
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FERMT1(55612)
mouse ... Fermt1(241639)
General description
Kindlin-1 is coded by FERMT1 (fermitin family member 1) gene. It is a focal adhesion protein, expressed in the skin and intestine. FERMT1 is located on human chromosome 20p.12.3.
Immunogen
synthetic peptide corresponding to a sequence close to the N-terminus of human Kindlin-1, conjugated to KLH. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).
Application
Monoclonal Anti-Kindlin-1 antibody has been used in immunohistochemistry, immunofluorescence staining and western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Kindlin-1 protein, coded by FERMT1 gene modulates keratinocyte electrotaxis. It participates in the initiation of the integrin family of extracellular matrix receptors. FERMT1 maintains the lamellipodial protrusions at the time of electrotaxis. Mutations in kindlin-1 results in Kindler syndrome (KS).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis
Wu CJ, et al.
Nature Communications, 6(4), 7531-7531 (2015)
Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing
Shen CS, et al.
International Journal of Molecular Medicine, 39(4), 949-959 (2017)
Case of Kindler syndrome resulting from mutation in the FERMT1 gene
Wada MM, et al.
The Journal of Dermatology, 39(12), 1057-1058 (2012)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200465-200UL | 04061837875564 |