SAB4200545
抗-小白蛋白抗体，小鼠单克隆
clone PARV-19, purified from hybridoma cell culture
别名:
单克隆抗-ALPHA-PARVALBUMIN, 单克隆抗-PALB1, 单克隆抗-PV, 单克隆抗-PVALB（包括 EG：19293）, 单克隆抗-Parv, 单克隆抗-Pva
产品名称
抗-小白蛋白抗体，小鼠单克隆, clone PARV-19, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
PARV-19, monoclonal
form
buffered aqueous solution
mol wt
antigen 12 kDa
species reactivity
rat, human
concentration
~1.0 mg/mL
technique(s)
immunohistochemistry: 5-10 μg/mL using formalin-fixed paraffin embedded rat cerebellum.
indirect immunofluorescence: 10-20 μg/mL using BLO-11 cells.
western blot: 1-2 μg/mL using mouse muscle extracts.
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PVALB(5816)
rat ... PVALB(25269)
Application
小鼠单克隆抗小白蛋白抗体可用于：
- 免疫组织化学
- 免疫荧光染色
- 免疫标记
- 标记大脑切片用于围神经网络的染色
- 酶联免疫吸附试验(ELISA)
- 免疫细胞化学
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1 篇论文）
蛋白质免疫印迹分析（1 篇论文）
Biochem/physiol Actions
Ca2+ 参与细胞运动、神经递质释放、膜渗透性、 激发−肌肉收缩、细胞分泌过程和神经冲动的传递 。胞内 Ca2+ 交换剂对于这些过程的调节至关重要。小白蛋白（PV）是一种钙结合蛋白，可以调节神经元中胞内钙的动力学性质。因此，它可以影响突触的易化和抑制。有趣的是，PV缺乏会改变神经元活性，这是导致癫痫发作和帕金森症的一种主要机制。
单克隆抗小白蛋白抗体以Ca2+离子依赖的方式识别小白蛋白 。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
抗小白蛋白单克隆抗体（小鼠IgG1同种型）来源于小鼠骨髓瘤细胞和以纯化青蛙肌肉小白蛋白免疫的BALB/c小鼠脾细胞融合产生的杂交瘤PARV-19。小白蛋白（PV）是Ca2+结合分子家族中的一员。它带有三个具有螺旋-环-螺旋EF-hand 结构的Ca2+结合域。
Immunogen
纯化的青蛙肌肉小白蛋白。该同种型是通过 ELISA 法，使用小鼠单克隆抗体同种型试剂（Sigma ISO-2） 确定的。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Preparation Note
若需延长储存时间，可将溶液分装并在-20 °C下冷冻。不建议反复冻融或存放在“无霜”冰柜中。如果长期储存时出现轻微浑浊，请在使用前通过离心澄清溶液。若工作稀释样品在12小时内未使用完，则应丢弃。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Syed Hasan Arif
BioEssays : news and reviews in molecular, cellular and developmental biology, 31(4), 410-421 (2009-03-11)
Parvalbumins (PVs) are acidic, intracellular Ca(2+)-binding proteins of low molecular weight. They are associated with several Ca(2+)-mediated cellular activities and physiological processes. It has been suggested that PV might function as a "Ca2+ shuttle" transporting Ca2+ from troponin-C (TnC) to
Rachel Schroeder et al.
Antioxidants & redox signaling, 35(7), 511-530 (2021-01-28)
Aims: Impaired embryonic cortical interneuron development from prenatal stress is linked to adult neuropsychiatric impairment, stemming in part from excessive generation of reactive oxygen species in the developing embryo. Unfortunately, there are no preventive medicines that mitigate the risk of
Angela E Gonzalez et al.
Frontiers in cellular neuroscience, 16, 932391-932391 (2022-08-16)
Parvalbumin (PV)-positive cells are GABAergic fast-spiking interneurons that modulate the activity of pyramidal neurons in the medial prefrontal cortex (mPFC) and their output to brain areas associated with learning and memory. The majority of PV cells within the mPFC are
Stephanie J Lussier et al.
Developmental neurobiology, 76(10), 1078-1091 (2016-01-03)
Prenatal stress is associated with altered behavioral, cognitive, and psychiatric outcomes in offspring. Due to the importance of GABAergic systems in normal development and in psychiatric disorders, prenatal stress effects on these neurons have been investigated in animal models. Prenatal
Kyle A Sullivan et al.
International journal of molecular sciences, 24(14) (2023-07-29)
Over a third of patients with temporal lobe epilepsy (TLE) are not effectively treated with current anti-seizure drugs, spurring the development of gene therapies. The injection of adeno-associated viral vectors (AAV) into the brain has been shown to be a
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