SAB4200697
抗 酪氨酸羟化酶抗体，小鼠单克隆
clone TH-16, purified from hybridoma cell culture
别名:
TH, TYH
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NACRES:
NA.44
UNSPSC Code:
12352203
Clone:
TH-16, monoclonal
Species reactivity:
rat, dog, rabbit, human, sheep, guinea pig, mouse, monkey, bovine
Application:
IHC, IP
Citations:
10
Quality Level
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
TH-16, monoclonal
form
buffered aqueous solution
species reactivity
rat, dog, rabbit, human, sheep, guinea pig, mouse, monkey, bovine
concentration
~1 mg/mL
technique(s)
immunoblotting: 1-2 μg/mL using whole extract of rat PC-12 cells, immunohistochemistry: suitable, immunoprecipitation (IP): suitable
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TH(7054)
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General description
抗酪氨酸羟化酶单克隆抗体（小鼠IgG1同种型）来源于小鼠骨髓瘤细胞和以纯化大鼠酪氨酸羟化酶免疫的BALB/c小鼠脾细胞融合产生的杂交瘤TH-16。该抗体识别人、猴、牛、羊、兔、狗、豚鼠、小鼠和大鼠的酪氨酸羟化酶(TH)N端位点。
酪氨酸羟化酶(TH)由定位于人染色体11p15的基因编码。酪氨酸羟化酶是由四个相同亚基组成的四聚体，特有调节性、催化性和四聚化结构域。酪氨酸羟化酶以酪氨酸、BH4和O2为共同底物，Fe2+ 为辅因子。
酪氨酸羟化酶(TH)由定位于人染色体11p15的基因编码。酪氨酸羟化酶是由四个相同亚基组成的四聚体，特有调节性、催化性和四聚化结构域。酪氨酸羟化酶以酪氨酸、BH4和O2为共同底物，Fe2+ 为辅因子。
Immunogen
纯化大鼠酪氨酸羟化酶
Biochem/physiol Actions
酪氨酸羟化酶（TH）催化儿茶酚胺神经递质生物合成的第一个限速步骤，即L-酪氨酸转化为L-多巴。L--苯丙氨酸对TH的抑制可能在苯丙酮尿症中发挥关键作用，并阻止去甲肾上腺素的合成。TH 活性可通过磷酸化来调节。TH的表达降低与多种神经精神疾病，例如精神分裂症和帕金森病 (PD)。
Physical form
溶于含有15 mM叠氮化钠的0.01 M磷酸盐缓冲液（pH 7.4）
Preparation Note
如需连续使用，可在2-8°C下保存一个月。对于长期储存，可将工作浓度的分装品冷冻。不建议反复冻融。如果长期储存时出现轻微混浊，通过离心澄清溶液。如果在12小时内未使用，则应丢弃工作稀释样品。
Other Notes
为了在各种技术和制备中获得最结果，我们建议用滴定法测定最佳工作浓度。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Chun Chen et al.
NPJ Parkinson's disease, 7(1), 39-39 (2021-05-14)
Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain sections. Mitochondrial dysfunction, particularly deficiency in complex I
Chang Chen et al.
Metabolic brain disease, 34(1), 203-212 (2018-11-15)
Parkinson's disease (PD) is a common chronic neurodegenerative disease and greatly affects the quality of PD patients' life. Current symptomatic treatment of PD is limited. There are no effective treatment and drugs that could radically cure PD. Increasing experimental evidence
TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
NAGATSU T, et al.
The Journal of Biological Chemistry, 2910-2917 (1964)
Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines.
Nakashima A, et al.
Journal of neural transmission (Vienna, Austria : 1996), 116, 1355-1362 (2009)
Guoxue Zhu et al.
Aging, 13(15), 19510-19528 (2021-08-03)
Parkinson's disease (PD), the typical neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN). However, no therapeutic agent used currently could slow down neuronal cell loss so as to decelerate or halt the
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