SAB4200724
抗-AGO2抗体,小鼠单克隆
clone AGO2-10, purified from hybridoma cell culture
别名:
抗-Argonaute2, 抗-PAZ Piwi域蛋白(PPD), 抗-eIF2C 2, 抗-真核翻译起始因子2C 2, 抗-精氨酸RISC催化组分2, 抗-蛋白Argonaute 2
产品名称
抗-AGO2抗体,小鼠单克隆, clone AGO2-10, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
AGO2-10, monoclonal
form
buffered aqueous solution
mol wt
~95 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoblotting: 2-4 μg/mL using extract of HEK-293T cells transfected with human AGO2
immunoprecipitation (IP): 10-20 μg/test using HeLa cells extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AGO2(27161)
Application
抗-AGO2小鼠单克隆抗体已被用于免疫印迹和免疫沉淀。
Biochem/physiol Actions
Argonaute 2（AGO2）具有内在的核酸内切酶活性。它能以小RNA向导的方式直接切割mRNA。AGO2可作为RNA诱导的沉默复合物（RISC）的必要催化成分在RNA沉默过程中起核心作用。它对于稳定细胞外体液中外泌体中的循环microRNA（miRNA）中具有重要作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
抗-AGO2小鼠单克隆抗体（小鼠IgG1同工型）来源于用人AGO2蛋白C-末端区域并与匙孔血蓝蛋白（KLH）偶联的合成肽免疫的BALB/c小鼠骨髓瘤细胞，和脾细胞相互融合而产生的AGO2-10杂交瘤细胞。AGO2也称为蛋白argonaute 2、argonaute RNA诱导的沉默复合物（RISC）催化成分2、真核翻译起始因子2C 2（eIF2C2）和PAZ Piwi域蛋白（PPD）。Argonaute 2（AGO2）属于Argonaute家族。它定位于人类染色体8q24。Ago蛋白定位于体细胞的细胞质，并在细胞质加工体中浓缩。
Immunogen
对应于人AGO2蛋白C末端区域的合成肽，其与KLH偶联。
Physical form
溶于含有 15 mM 叠氮化钠的 0.01M 磷酸盐缓冲盐水（pH 7.4）溶液中。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster
Van RRP, et al.
Genes & Development, 20(21), 2985-2995 (2006)
Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma
Cheng N, et al.
Hepatology, 57(5), 1906-1918 (2013)
Argonaute2 expression is post-transcriptionally coupled to microRNA abundance
Martinez NJ and Gregory RI
RNA, 19(5), 605-612 (2013)
Zhenyu Li et al.
Cancer cell international, 20, 294-294 (2020-07-17)
Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unclear, so it remains to be explored.
Mahmoud Kandeel et al.
PloS one, 9(5), e94538-e94538 (2014-05-03)
Gene silencing and RNA interference are major cellular processes that control gene expression via the cleavage of target mRNA. Eukaryotic translation initiation factor 2C2 (EIF2C2, Argonaute protein 2, Ago2) is considered to be the major player of RNAi as it
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持