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Merck
CN

SAB4300001

抗-磷酸化-GSK3B (pSer9) 兔抗

affinity isolated antibody

别名:

抗-糖原合酶激酶3β 兔抗

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
indirect immunofluorescence
western blot
Species reactivity:
mouse, rat, human
Citations:
5
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
Uniprot accession no.:
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产品名称

抗-磷酸化-GSK3B (pSer9) 兔抗, affinity isolated antibody

Quality Level

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~46 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(T-T-SP-F-A)

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer9)

Gene Information

human ... GSK3B(2932)

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Features and Benefits

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General description

参与Wnt信号通路。与包括糖原合成酶、MYB和转录因子JUN在内的几种调节蛋白的激素控制有关。使JUN在其DNA结合结构域附近的位点磷酸化,从而降低了其对DNA的亲和力。磷酸化乳腺癌细胞中的MUC1,并减少MUC1与CTNNB1/β-连环蛋白的相互作用。磷酸化CTNNB1/β-连环蛋白。

Immunogen

基于蛋白质GSK3B的丝氨酸9(T-T-S(p)-F-A)磷酸化位点周围的肽序列。

Physical form

溶于含有0.02%叠氮化钠和50%甘油的磷酸盐缓冲液

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Shayesteh Mehdinejadiani et al.
Biology of reproduction, 100(3), 641-648 (2018-09-06)
Polycystic ovary syndrome (PCOS) is an endocrine disorder in women of reproductive age. In addition to anovulation, endometrial dysfunction can reduce fertility in PCOS. The cyclical changes of endometrium are controlled by estrogen and progesterone via modulating the Wnt/B-catenin pathway.
Xiujing Feng et al.
Journal of cellular physiology, 234(10), 18994-19009 (2019-03-29)
Acute kidney injury (AKI) is a frequent and serious complication of sepsis; however, there are currently no effective therapies. Inflammation and oxidative stress are the major mechanisms implicated in lipopolysaccharide (LPS)-induced AKI. Dexmedetomidine (DEX) has been reported to have remarkable
Yea-Hwey Wang et al.
Food & function, 10(8), 4725-4738 (2019-07-16)
Antrodia camphorata is a well-known traditional Chinese mushroom used as a functional food and nutraceutical in Taiwan and China. The aim of this study was to explore the protective effects and mechanism(s) of the ethyl acetate crude extract of A.
Pilar Sánchez-Blázquez et al.
The international journal of neuropsychopharmacology, 21(10), 938-948 (2018-06-04)
Several currently available animal models reproduce select behavioral facets of human mania as well as the abnormal glutamatergic neurotransmission and dysregulation of glycogen synthase kinase 3β that accompanies this disease. In this study, we addressed the therapeutic potential of ligands
Jianping Guo et al.
Nature cell biology, 21(2), 226-237 (2019-01-30)
Aberrant activation of AKT disturbs the proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand the upstream signalling pathways governing AKT activation. Here, we report that AKT undergoes SETDB1-mediated lysine methylation to promote its

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